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Construction and Functionalization of Rotaxane and Polyrotaxane Immobilized on Gold Substrate for Molecular Devices

分子器件金基底固定轮烷和聚轮烷的构建及功能化

基本信息

批准号：
21350061
负责人：
KIMURA Shunsaku
金额：
$ 12.81万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2009
资助国家：
日本
起止时间：
2009 至 2011
项目状态：
已结题

项目摘要

Various cyclic.-peptides were synthesized as a ring component of rotaxanes. Those cyclic peptides were 1) cyclic tri-.-peptide of cyclo(4-(4-pyridyl)-.-homoalanine) 3, 2) cyclic tri-.-peptide composed of two.-glucosamino acid residues and a trans-2-aminocyclohexylcarboxylic acid residue, 3) cyclic tetra-.-peptide composed of three.-alanine residues and a L-.-homolysine residue having 10, 12-pentacosadiynoic amide at the side chain, 4) cyclic hexa-.-peptide composed of six.-glucosamino acid residues, and 5) cyclic hexa-.-peptides having three glysine residues or three lipoic acids at the side chains. All these cyclic.-peptides were found to form peptide nanotubes under suitable conditions. The peptide nanotube composed of cyclo(4-(4-pyridyl)-.-homoalanine) 3 was subjected to electroless plating to yield a Ni nanotube. The other cyclic tri-.-peptide composed of two.-glucosamino acid residues and a trans-2-aminocyclohexylcarboxylic acid residue formed a bundle of the peptide nanotube with nine columns in a bundle. The cyclic tetra-b-peptide formed a peptide nanotube with extending the 10, 12-pentacosadiynoic amide chain toward the same surface of the nanotube, which allowed polymerization of the diacetylene units along the peptide nanotube. The cyclic hexa-?-peptide took two types of conformations, which became an obstacle to construct the rotaxane structure on gold surface. The experimental conditions for preparation of the rotaxane on gold surface remain to be found out.

各种各样的循环。-多肽作为轮烷的环组分合成。这些环状肽为1)环状三-。-环(4-（4-吡啶基）-的肽。-同丙氨酸)3,2)环三-。-由两个肽组成。-葡萄糖氨基酸残基和反式-2-氨基环己基羧酸残基，3)环四。-由三个肽组成。-丙氨酸残基和L-。-侧链上有10,12 -五乙酸二胺的同赖氨酸残基，4)环六。-由6个肽组成。-氨基葡萄糖残基和5)环六-。-在侧链上有三个甘氨酸残基或三个硫辛酸的肽。这些都是循环的。-肽在合适的条件下形成肽纳米管。由环(4-（4-吡啶基）-组成的肽纳米管。对-同丙氨酸)3进行化学镀得到镍纳米管。另一个环三。-由两个肽组成。-葡萄糖氨基酸残基和反式-2-氨基环己基羧酸残基组成了一束九柱的肽纳米管。环四b肽形成了一个肽纳米管，其10,12 -五甲酸二胺链向纳米管的同一表面延伸，这使得二乙炔单元沿着肽纳米管聚合。环六-？-肽具有两种构象，这成为在金表面构建轮烷结构的障碍。在金表面制备轮烷的实验条件还有待研究。