Mechanical properties and cell proliferation characteristic of functionally graded porous composite materials for bone tissue regeneration

具有增强结构的基于PLLA的支架已经被开发用于骨组织再生。研究发现，致密壳、多孔壳、单梁和双梁四种不同的增强体均能显著提高混凝土的压缩模量和强度。还发现，添加生物活性陶瓷如HA和.- TCP进入PLLA基质后大大提高了支架的细胞增殖和ALP活性。胶原/β-TCP支架也已被开发用于改善生物活性。与纯胶原支架相比，干细胞复合支架具有更好的细胞增殖和分化行为，并具有更高的力学性能。研究还表明，压缩性机械刺激可以促进支架内细胞增殖和ALP活性。

PLLA based scaffolds with reinforced structures have been developed for bone tissue regeneration. Four different kinds of reinforcements, dense shell, porous shell, one beam and two beams, have been introduced and it was found that the compressive modulus and strength are dramatically improved. It was also found that addition of bioactive ceramics such as HA and.-TCP into the PLLA matrix greatly improve the cell proliferation and ALP activity of the scaffold. Collagen/β-TCP scaffold has also been developed to improve bioactivity. This composite scaffold hybridized with stem cells was found to show better cell proliferation and differentiation behavior and have higher mechanical property than pure collagen scaffold with stem cells. It was also clarified that compressive mechanical stimulus can improve the cell proliferation and ALP activity within scaffolds.