Mechanical properties and cell proliferation characteristic of functionally graded porous composite materials for bone tissue regeneration

用于骨组织再生的功能梯度多孔复合材料的力学性能和细胞增殖特性

• 批准号: 21360054
• 负责人: TODO Mitsugu
• 金额: $ 8.57万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21360054/
• 关键词: 材料設計; プロセス; 物性; 評価; 生体材料; 複合材料; 再生医療; 骨再生; 多孔質材料; 間葉系幹細胞; 多孔質構造

PLLA based scaffolds with reinforced structures have been developed for bone tissue regeneration. Four different kinds of reinforcements, dense shell, porous shell, one beam and two beams, have been introduced and it was found that the compressive modulus and strength are dramatically improved. It was also found that addition of bioactive ceramics such as HA and.-TCP into the PLLA matrix greatly improve the cell proliferation and ALP activity of the scaffold. Collagen/β-TCP scaffold has also been developed to improve bioactivity. This composite scaffold hybridized with stem cells was found to show better cell proliferation and differentiation behavior and have higher mechanical property than pure collagen scaffold with stem cells. It was also clarified that compressive mechanical stimulus can improve the cell proliferation and ALP activity within scaffolds.

pla基增强结构支架是一种用于骨组织再生的材料。采用密壳、多孔壳、单梁和双梁四种不同的加固方法，显著提高了混凝土的抗压模量和强度。同时还发现，添加生物活性陶瓷如透明质酸和。-TCP加入到PLLA基质中，大大提高了支架细胞的增殖能力和ALP活性。胶原/β-TCP支架也被开发用于提高生物活性。与纯胶原干细胞复合支架相比，该复合支架具有更好的细胞增殖和分化行为，力学性能也更高。压缩机械刺激可提高支架内细胞增殖和ALP活性。

项目成果

The variation of mechanical characteristic of collagen scaffold with mesechymal stem cell

间充质干细胞胶原支架力学特性的变化

• 发表时间: 2011
• 作者: K. Murota;Keisuke Tanaka;Takaaki Arahira and Mistugu Todo
• 通讯作者: Takaaki Arahira and Mistugu Todo

The effect of bimodal distribution on the mechanical properties of hydroxyapatite particle filled poly(L-lactide) composites

• DOI: 10.1016/j.jmbbm.2008.06.001
• 发表时间: 2009-01-01
• 期刊: JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
• 影响因子: 3.9
• 作者: Takayama, Tetsuo;Todo, Mitsugu;Takano, Atsushi
• 通讯作者: Takano, Atsushi

Compressive mechanical properties and deformation behavior of PLLA/HAp and PLLA/PCL scaffolds

PLLA/HAp和PLLA/PCL支架的压缩力学性能和变形行为

• 发表时间: 2010
• 作者: 佐々木淳;池野順一;Joo-Eon Park and Mitsugu Todo
• 通讯作者: Joo-Eon Park and Mitsugu Todo

骨組織形成による多孔質バイオセラミックスの力学特性変化に関する研究

骨组织形成引起的多孔生物陶瓷力学性能变化的研究

• 发表时间: 2010
• 作者: 荒平高章;東藤貢;名井陽
• 通讯作者: 名井陽

複合構造化による吸収性多孔質材料の高強度化

通过复合结构提高吸收性多孔材料的强度

• 发表时间: 2010
• 作者: Makoto SASAKI;Junichi IKENO;朴冑彦,東藤貢
• 通讯作者: 朴冑彦,東藤貢