Mechanisms regulating developmental fate and sex differences of the germline in Drosophiala embryos

本研究试图阐明果蝇生殖细胞发育命运和性别差异的调控机制。生殖细胞是如何决定自己的性别的，这仍然是一个令人着迷的谜。在这里，我们表明，一个单一的基因（Sxl）可以启动原始生殖细胞（PGCs）的女性性发育。我们的研究结果为将来的工作铺平了道路，这将有助于建立性别决定机制在生殖细胞中的保守程度。

In this study, we have been trying to clarify the mechanisms regulating developmental fate and sex differences of the germ cells in Drosophila. What has remained a fascinating puzzle is how the germ cell decides its own sex. Here, we show that a single gene(Sxl) can initiate female sexual development in the primordial germ cells(PGCs). Our findings pave the way for future work that will help to establish the extent to which sex detemination mechanism is conserved in germ cell.