Gene networks underlying development of the Drosophila central nervous system

果蝇视神经板层和延髓视神经节发育的分子机制已被研究。我们已经确定了（1）层前体细胞和视网膜轴突之间识别所需的细胞表面分子，（2）EGFR和Notch信号通路的协调顺序作用，以精确有序的方式诱导髓质成神经细胞形成。我们还确定了参与平面细胞极性和肌动蛋白重塑的基因，这些基因是调节轴突伸长和指导蘑菇体（嗅觉记忆形成的中心）的重要参与者。

The molecular mechanisms underlying development of Drosophila lamina and medulla optic ganglia have been studied. We have identified(1) cell surface molecules that are required for recognition between lamina precursor cells and retinal axons,(2) coordinated sequential action of the EGFR and Notch signaling pathways that induce medulla neuroblasts formation in a precisely ordered manner. We have also identified genes involved in planer cell polarity and actin remodeling as important players that regulate axon elongation and guidance of the mushroom body, the center of the olfactory memory formation.