Studies on opportunistic infection mechanisms of lactobacilli and bifidobacteria

我们发现几株乳杆菌都能侵入Caco-2细胞单层。其中，对入侵部位和入侵机制进行了进一步的研究，其中入侵最强的菌株为卷曲乳杆菌JCM 5810。结果表明，细菌通过顶端进入细胞，细菌中的蛋白质合成和Caco-2细胞内微丝的重排是入侵的关键。

We find out that several Lactobacillus strains can invade Caco-2 cell monolayer. Among those, the most invasive strain Lactobacillus crispatus JCM 5810 was used further studies on an invasive site and mechanism. It was shown that the bacterium enters the cells via apical side, and protein synthesis in the bacteria and rearrangement of microfilaments inside Caco-2 cells are essential for the invasion.