Functions of gicerin, a cell adhesion molecule in development, memory and oncogenesis of animals

本研究探讨了gicerin在动物发育、记忆和肿瘤发生中的表达及其功能。鸡皮肤真皮自体移植物中出现吉色林，并促进移植物上皮的再生。此外，gicerin促进肿瘤细胞，包括结肠直肠癌细胞和马立克氏病的转移活动。Gicern基因敲除小鼠在发育过程中是完全致死的，因此其在器官发生和记忆中的潜在作用仍有待阐明。

In this study, the expression and functions of gicerin were examined in development, memory and oncogenesis of animals. Gicerin appeared in the skin dermal autografs of chickens and promoted the regeneration of epithelia of grafts. Furthermore, gicerin promoted the metastatic activities of tumor cells including colorectal cancer cells and marek's disease. Gicern knockout mice were totally lethal in development, thus its potential role in organogenesis and memory remains to be elucidated.