Molecular analysis of resistant mechanisms against both hypoxic and pro-apoptotic stimulation in malignant hematopoietic cell tumors.

在细胞的肿瘤发展过程中，最严重的恶性获得性特征是通过细胞死亡信号的失活而导致的异常增殖和凋亡抵抗。在本研究中，我分析了在低氧环境下，血液系统恶性肿瘤中依赖线粒体的内源性凋亡过程的失能机制和细胞功能维持机制。并寻找具有抗癌作用的分子靶向药物。研究低氧诱导因子与核因子κB的相互作用对细胞凋亡的抑制作用。

he malignant acquired character that is the most serious in the tumor development of the cell is the abnormal proliferation and apoptosis resistance by the disablement of the cell death signal. In this study, I analyzed the disablement mechanism of the endogenous apoptotic process dependent on the mitochondria in the haematopoietic malignant tumor and cell function maintenance mechanism under the hypoxia environment. I also searched for the molecular target medicine which showed anti-cancer property. The crosstalk of the hypoxia-inducible factor(HIF) and NF-κB resulting in apoptosis resistance was investigated.