The development of innovative asy mmetric synthetic methods by the enzyme-metal combo catalysis

通过结合使用水解酶和钒化合物，设计了一种将外消旋烯丙醇转化为光学纯化合物的新方法。该项目的结果为光学活性化合物的不对称合成提供了一个创新的概念，这对于药物发现研究是必不可少的。值得注意的是，为了实现酶和氧钒化合物这两种高活性催化剂的原有功能，而不在单个反应容器中相互失活，使用介孔二氧化硅有效地划分了它们的工作空间。

A new methodology for the conversion of racemic allyl alcohols into optically pure compounds was devised by the combined use of hydrolases and vanadium compounds. The results of this project present an innovative concept for the asymmetric synthesis of optically active compounds which is essential for the drug discovery research. It is noteworthy that in order to fulfill the original functions of the two highly reactive catalysts ; viz., enzymes and the oxovanadium compound, without mutual deactivation in a single reaction vessel, mesoporous silica was effectively employed to divide their work space.