Research and development of drugs of prevention and treatment for complication of diabetes targeting the receptor of advanced glycation end products(RAGE)

糖尿病最严重的三种并发症；视网膜病变、肾炎和神经症，都是由于AGE与其受体结合在血管内皮细胞中引起的现象。（AGE; Advanced Glycation End products，血液中蛋白质与糖的反应产物）本课题的目的是结合核磁共振、x射线晶体学、构象能计算和超离心分析、等温滴定量热法等获得的热力学信息，通过合理设计和化学合成候选药物来抑制这种相互作用，开发治疗糖尿病血管并发症的药物。

The worst three complications of diabetes ; retinopathy, nephritis and neurosis, are due to phenomena in vascular endothelial cells induced by the binding of AGE to its receptor.(AGE ; Advanced Glycation End products, the reaction products between protein and sugar in blood) The aim of this project is to develop therapeutic agents for diabetic vascular complications by rational design and chemical synthesis of candidates to inhibit this interaction with considering the structural information obtained by NMR, X-ray crystallography, conformation energy calculation and thermodynamic information by ultracentrifugation analysis and isothermal titration calorimetry and so on.