Effects of nanomaterial exposure on cranial nerve system of offspring
Effects of nanomaterial exposure on cranial nerve system of offspring
批准号:
21390037
负责人:
TAKEDA Ken
金额:
$11.9万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
The present study showed the effects of maternal exposure to nanomaterials on the development of cranial nerve system of offspring, using electron microscopic analysis, histological analysis, neurochemical(monoamine) analysis as well as gene expression analysis. The results indicated that exposure of pregnant mice to nanomaterial frequently used in nanotechnology induced alterations of microstructures, monoamine and its metabolism in the brain of offspring during the developmental period. Gene expression analysis using microarray showed an important clue of the mechanisms underlying the effects of maternal exposure to nanomaterials on the brain development.
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「ナノマテリアルの次世代健康影響-妊娠期曝露の子に及ぼす影響」
“纳米材料的下一代健康影响 - 怀孕期间接触纳米材料对儿童的影响”
DOI:
--
发表时间:
2011
期刊:
YAKUGAKU ZASSHI
影响因子:
0.3
作者:
[武田 健, 新海雄介, 鈴木健一郎, 柳田信也, 梅澤雅和, 横田理, 田井中均, 押尾茂, 井原智美, 菅又昌雄]
通讯作者:
菅又昌雄
分散物及び脳神経変性疾患治療薬
弥散和神经退行性疾病治疗
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[]
通讯作者:
Current research and prospect for health effects of nanoparticles on offspring.
纳米粒子对后代健康影响的研究现状及展望.
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Umezawa M, Takeda K.]
通讯作者:
Takeda K.
ディーゼル排気微粒子胎仔期曝露が老齢マウスのコリン神経系に影響を及ぼす
产前暴露于柴油机尾气颗粒会影响老年小鼠的胆碱能神经系统
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[横田理, 柳田信也, 武田健]
通讯作者:
武田健
Effects of exposure to titanium dioxide nanoparticles on activation of corticotrophin-releasing hormone neurons in pregnant rats and its offspring.
暴露于二氧化钛纳米颗粒对怀孕大鼠及其后代促肾上腺皮质激素释放激素神经元激活的影响。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Yanagita S, Kanemaru J, Umezawa M, Yokota S, Takeda K.]
通讯作者:
Takeda K.
共 52 条
Antitumor Effect of Zoledronic Acid-Loaded Phosphorylated Pullulan on Bone Metastasis Model of Mice.
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批准号:24791548
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项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.75万
-
财政年份:2012
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负责人:TAKEDA Ken
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依托单位:
Health effect of ionized particle from air purifier on the next generation
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批准号:23659361
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2011
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负责人:TAKEDA Ken
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依托单位:
Research on Structural Change of Supply Chain by Physical Distribution Innovation
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批准号:21653035
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$1.38万
-
财政年份:2009
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负责人:TAKEDA Ken
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依托单位:
Research on the induction of minimal brain dysfunction and symptoms of cranial nerve disease by prenatally exposure to nanoparticles in mice
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批准号:19390036
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.31万
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财政年份:2007
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负责人:TAKEDA Ken
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依托单位:
Study of prenatal exposure to diesel exhaust on male reproductive and central nerve systems of mice
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批准号:15390042
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.54万
-
财政年份:2003
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负责人:TAKEDA Ken
-
依托单位:
Studies on diesel exhaust on male reproductive system and its endocrine disrupting action
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批准号:12470511
-
项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.96万
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财政年份:2000
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负责人:TAKEDA Ken
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依托单位:
Change of characterization of human prostate cancer cells to neuronal cells by differentiation induction.
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批准号:10672060
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.79万
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财政年份:1998
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负责人:TAKEDA Ken
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依托单位:
Differentiation Therapy for Myeloblastic Leukemia-Establishment of New Strategy
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批准号:07672380
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.47万
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财政年份:1995
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负责人:TAKEDA Ken
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依托单位:
Induction of differentiation of human myelogenous leukemic cells and signal transduction
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批准号:04671369
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.41万
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财政年份:1992
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负责人:TAKEDA Ken
-
依托单位:
Studies on differentiation inducing factors for human myelogenous leukemic cells and enhancement of their activity.
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批准号:61571067
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.28万
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财政年份:1986
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负责人:TAKEDA Ken
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依托单位:
海外基金