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Antitumor Effect of Zoledronic Acid-Loaded Phosphorylated Pullulan on Bone Metastasis Model of Mice.

Antitumor Effect of Zoledronic Acid-Loaded Phosphorylated Pullulan on Bone Metastasis Model of Mice.
唑来膦酸磷酸化普鲁兰多糖对小鼠骨转移模型的抗肿瘤作用。
批准号:
24791548
负责人:
TAKEDA Ken
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31

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中文摘要
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英文摘要
We analyzed in vitro and in vivo antitumor effect of the mixture of zoledronic acid and phosphorylated pullulan for human breast cancer cell line. The elution of zoledronic acid released from phosphorylated pullulan exhibited antitumor effect. Phosphorylated pullulan exhibited a drug release property for zoledronic acid. The local administration of the mixture of the mixture of zoledronic acid and phosphorylated pullulan into the metastatic bone tumor model of nude mice exhibited antitumor effect. Furthermore, bone formation was observed around the mixture.
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DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [岩波明生, Paul S. Mischel, 岡野栄之, 戸山芳昭, 中村雅也, Ken Takeda]
通讯作者: Ken Takeda
Surgical treatment of Giant Cell Tumor of Bone in extremity.
四肢骨巨细胞瘤的手术治疗。
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [鈴木 悟士, 藤田 順之, 細金 直文, 渡邊 隆一, 日方 智宏, 岩波 明生, 渡邉 航太, 石井 賢, 戸山 芳昭, 田久保 圭誉, 堀内 圭輔, 宮本 健史, 中村 雅也, 松本 守雄, Ken Takeda]
通讯作者: Ken Takeda
Health effect of ionized particle from air purifier on the next generation
  • 批准号:
    23659361
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
  • 资助金额:
    $2.41万
  • 财政年份:
    2011
  • 负责人:
    TAKEDA Ken
  • 依托单位:
Research on Structural Change of Supply Chain by Physical Distribution Innovation
  • 批准号:
    21653035
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
  • 资助金额:
    $1.38万
  • 财政年份:
    2009
  • 负责人:
    TAKEDA Ken
  • 依托单位:
Effects of nanomaterial exposure on cranial nerve system of offspring
  • 批准号:
    21390037
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $11.9万
  • 财政年份:
    2009
  • 负责人:
    TAKEDA Ken
  • 依托单位:
Research on the induction of minimal brain dysfunction and symptoms of cranial nerve disease by prenatally exposure to nanoparticles in mice
  • 批准号:
    19390036
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $12.31万
  • 财政年份:
    2007
  • 负责人:
    TAKEDA Ken
  • 依托单位:
海外基金