Discovery and development of antitumor drugs focused on the molecular clock of dedifferentiation and apoptosis during carcinogenesis

生物钟系统与细胞周期和肿瘤发生有关。癌症患者中分子钟基因的表达发生改变。然而，在癌发生过程中分子钟改变的影响还没有被研究过。本研究通过下调细胞去分化相关基因的表达，抑制二乙基亚硝胺（DEN）诱发小鼠肝癌的作用。这些结果表明，细胞去分化相关基因的表达调控在肿瘤发生中起重要作用。

Circadian clock systems have been related in cell cycle and carcinogenesis. Theexpression of molecular clock genes is altered in cancer patients. However, the influenceof an alteration of molecular clock works during carcinogenesis has not been investigatedyet. In this study, the hepatocarcinogenesis by diethylnitrosoamine(DEN) in mice wasinhibited by the down-regulation of cellular dedifferentiation related genes expression. These findings suggest that the control of cellular dedifferentiation related genesexpression is important in carcinogenesis.