Role of molecular clock on the communication between each organ in organ dysfunction

点击翻译按钮获取中文摘要

Chronic kidney disease (CKD) increases the disease risk of apoplexy, cardiac failure, cardiac infarction and neurological complications. However, the mechanisms of these neurological complications remain unclear. Here, we showed the disruptive effect of chronic renal failure in 5/6 nephrectomy mice on the 24-hr rhythm of dopamine receptor and clock gene expressions in the striatum and cytochrome P450 (CYPs) in liver. These disruptive effects were induced by abnormal signal transduction in high Factor X expression from the kidney.