Role of molecular clock on the communication between each organ in organ dysfunction

分子钟在器官功能障碍中各器官之间通讯的作用

• 批准号: 23659084
• 负责人: OHDO Shigehiro
• 金额: $ 2.41万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659084/
• 关键词: 生体リズム; 分子時計; 臓器障害; 合併症

Chronic kidney disease (CKD) increases the disease risk of apoplexy, cardiac failure, cardiac infarction and neurological complications. However, the mechanisms of these neurological complications remain unclear. Here, we showed the disruptive effect of chronic renal failure in 5/6 nephrectomy mice on the 24-hr rhythm of dopamine receptor and clock gene expressions in the striatum and cytochrome P450 (CYPs) in liver. These disruptive effects were induced by abnormal signal transduction in high Factor X expression from the kidney.

慢性肾脏病（CKD）增加了中风、心力衰竭、心肌梗死和神经系统并发症的疾病风险。然而，这些神经系统并发症的机制仍不清楚。在这里，我们显示了5/6肾切除小鼠的慢性肾功能衰竭对纹状体多巴胺受体和时钟基因表达以及肝脏细胞色素P450（CYP）的24小时节律的破坏性影响。这些破坏性作用是由来自肾脏的高X因子表达中的异常信号转导诱导的。