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Mechanism for HMGB-or HMGB1-derived peptide-induced increase in BBB permeability

Mechanism for HMGB-or HMGB1-derived peptide-induced increase in BBB permeability
HMGB 或 HMGB1 衍生肽诱导 BBB 通透性增加的机制
批准号:
21390071
负责人:
NISHIBORI Masahiro
金额:
$11.73万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
A representative damage-associated molecular pattern, high mobility group box-1(HMGB1), was released from neuronal nuclei to extracellular space via cytosol after ischemia or traumatic brain injury. The released HMGB1 induced contractile response in vascular endothelial cells and pericytes leading to the increased permeability of BBB. Among HMGB1-derived peptides, some had plural activities. Anti-HMGB1 monoclonal antibody inhibited the BBB permeability and inflammatory responses induced by traumatic brain injury.
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Histamine inhibits adhesion molecule expression in human monocytes, induced by advanced glycation end products, during the mixed lymphocyte reaction.
在混合淋巴细胞反应过程中,组胺抑制人单核细胞中由晚期糖基化终产物诱导的粘附分子表达。
DOI: --
发表时间: 2010
期刊: Br J Pharmacol
影响因子: --
作者: [Zhang J, Liu K, Wake H, Nishibori M., et al.(11名、11番目)]
通讯作者: et al.(11名、11番目)
Advanced glycation end products enhance monocyte activation during human mixed lymphocyte reaction.
高级糖基化终产物增强人类混合淋巴细胞反应期间的单核细胞活化。
DOI: --
发表时间: 2010
期刊: Clin Immunol
影响因子: 8.6
作者: [Ohashi K, Liu K, Wake H, Nishibori M, et al., (11名、10番目)]
通讯作者: (11名、10番目)
Anti-high mobility group box1 monoclonal antibody protects blood-brain barrier from ischemic insult in rat
抗高迁移率族box1单克隆抗体保护大鼠血脑屏障免受缺血性损伤
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Honma, S., Liu K]
通讯作者: Liu K
Prostaglandins E2 inhibits advanced glycation end products-induced adhesion molecule expression, cytokine production and lymphocyte proliferation in human peripheral blood mononuclear cells
前列腺素 E2 抑制人外周血单核细胞中晚期糖基化终末产物诱导的粘附分子表达、细胞因子产生和淋巴细胞增殖
DOI: --
发表时间: 2009
期刊: J Pharmacol Exp Ther
影响因子: 3.5
作者: [Takahashi HK, Liu K, Wake H, Nishibori M, et al., (8名、8番目)]
通讯作者: (8名、8番目)
36
    Drug development for brain and spinal cord trauma targeting HMGB1
    • 批准号:
      24390061
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $12.15万
    • 财政年份:
      2012
    • 负责人:
      NISHIBORI Masahiro
    • 依托单位:
    Development oftherapy for acute traumatic brain injury
    • 批准号:
      23659687
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.41万
    • 财政年份:
      2011
    • 负责人:
      NISHIBORI Masahiro
    • 依托单位:
    Proteomics analysis of plasma protein complex regulating leukocyte interaction.
    • 批准号:
      15590228
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.3万
    • 财政年份:
      2003
    • 负责人:
      NISHIBORI Masahiro
    • 依托单位:
    Application of Spectral Imaging Technology to a New Non-invasive Visual Diagnostic Method
    • 批准号:
      15590480
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.24万
    • 财政年份:
      2003
    • 负责人:
      NISHIBORI Masahiro
    • 依托单位:
    海外基金