Development oftherapy for acute traumatic brain injury
Development oftherapy for acute traumatic brain injury
批准号:
23659687
负责人:
NISHIBORI Masahiro
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
High mobility group box-1 (HMGB1 )has been paid much attention as an important damage-associated molecular pattern. I established anti-HMGB1 antibody therapy for ischemic brain injury and brain vasospasm. In the present study, I examined whether anti-HMGB1 antibody therapy may exert beneficial effects on traumatic brain injury in rats. The results showed that HMGB1 in neurons at injured site was translocated and released into extracellular space. The administration of anti-HMGB1 antibody inhibited the disruption of blood-brain barrier and resulting brain edema. Anti-HMGB1 antibody therapy will be beneficial for the treatment of traumatic brain injury.
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血管内アプローチを用いた低侵襲サル中大脳動脈閉塞モデルの作製法
一种利用血管内途径建立微创猴大脑中动脉闭塞模型的方法
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Onishi M , Kurozumi K , Ichikawa T , Michiue H , Fujii K , Ishida J , Shimazu Y , Chiocca EA , Kaur B , Date I, 大熊佑]
通讯作者:
大熊佑
B細胞悪性リンパ腫治療薬
B细胞恶性淋巴瘤治疗药物
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[]
通讯作者:
好中球活性化調節剤
中性粒细胞活化调节因子
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[]
通讯作者:
DOI:
10.3109/02713683.2011.594201
发表时间:
2010-04
期刊:
Current Eye Research
影响因子:
2
作者:
[Shenyang Yang;K. Hirooka;Ye Liu;Tomoyoshi Fujita;Kouki Fukuda;Takehiro Nakamutra;T. Itano;Jiyong Zhang;M. Nishibori;F. Shiraga]
通讯作者:
Shenyang Yang;K. Hirooka;Ye Liu;Tomoyoshi Fujita;Kouki Fukuda;Takehiro Nakamutra;T. Itano;Jiyong Zhang;M. Nishibori;F. Shiraga
炎症性サイトカインHMGB1をターゲットにした新規脳梗塞治療抗体-抗体治療の展開
开发针对炎症细胞因子HMGB1的新型脑梗塞治疗抗体疗法
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Tsuchida R, et al., Yoh Takuwa, 西堀正洋]
通讯作者:
西堀正洋
共 38 条
Drug development for brain and spinal cord trauma targeting HMGB1
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批准号:24390061
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.15万
-
财政年份:2012
-
负责人:NISHIBORI Masahiro
-
依托单位:
Mechanism for HMGB-or HMGB1-derived peptide-induced increase in BBB permeability
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批准号:21390071
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.73万
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财政年份:2009
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负责人:NISHIBORI Masahiro
-
依托单位:
Proteomics analysis of plasma protein complex regulating leukocyte interaction.
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批准号:15590228
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
-
财政年份:2003
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负责人:NISHIBORI Masahiro
-
依托单位:
Application of Spectral Imaging Technology to a New Non-invasive Visual Diagnostic Method
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批准号:15590480
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2003
-
负责人:NISHIBORI Masahiro
-
依托单位:
Internet Based Control Survey for the Morphological Laboratory Tests
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批准号:10672172
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.05万
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财政年份:1998
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负责人:NISHIBORI Masahiro
-
依托单位:
A role of a novel brain-derived proteinase inhibitor in the apoptosis in neurons
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批准号:09670092
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.66万
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财政年份:1997
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负责人:NISHIBORI Masahiro
-
依托单位:
海外基金