The development of a mini-array specific to gastric cancers to estimate biological characteristics

开发胃癌特异性微型阵列来评估生物学特性

• 批准号: 21390106
• 负责人: SASAKI Kohsuke
• 金额: $ 11.73万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390106/
• 关键词: がん; ゲノム; DNAコピー数; アレイCGH; CGH; WGAS; ミニアレイ; 胃癌; 大腸癌; 癌病態; 悪性度

We developed the" mini-array" for gastric cancer to evaluate biological characteristics including lymph node metastasis and so on. In order to select BAC clones linked with biological characteristics, we applied a technology of array-based CGH to gastric cancers. To evaluate the" mini-array" for gastric cancer, we applied" mini-array" for another case of gastric cancers and we succeeded in predicting correctly about 70% of cases with no lymph node metastasis. This result suggests the" mini-array" a useful device for personalized treatment for cancers.

我们开发了针对胃癌的“微阵列”，以评估包括淋巴结转移等在内的生物学特性。为了筛选与生物学特性相关的BAC克隆，我们将一种基于阵列的CGH技术应用于胃癌。为了评估“微阵列”在胃癌中的应用，我们将“微阵列”应用于另一例胃癌，我们成功地正确预测了大约70%的无淋巴结转移的病例。这一结果表明，“微型阵列”是一种用于癌症个性化治疗的有用设备。

项目成果

Centrosome ampliication as a putative prognostic biomarker for the classification of urothelial carcinomas

中心体扩增作为尿路上皮癌分类的假定预后生物标志物

• 发表时间: 2011
• 期刊: human pathology
• 影响因子: 3.3
• 作者: Inagaki H;Ohye T;Kogo H;Kato T;Bolor H;Taniguchi M;Shaikh TH;Emanuel BS;Kurahashi H;Yamamoto Y
• 通讯作者: Yamamoto Y

Screening for DNA copy number aberrations in mucinous adenocarcinoma arising from the minor salivary gland : two case reports

筛查小唾液腺粘液性腺癌中的 DNA 拷贝数畸变：两例报告

• 发表时间: 2010
• 期刊: Cancer Genet Cytogenet
• 作者: Uchida K;Oga A;Nagatsuka H;Ueyama Y;Sasaki K
• 通讯作者: Sasaki K

Genomic instability and DNA ploidy are linked to DNA copy number aberrations of 8p23 and 22q11.23 in gastric cancers.

• DOI: 10.3892/ijmm_00000470
• 发表时间: 2010-09
• 期刊: International journal of molecular medicine
• 影响因子: 5.4
• 作者: S. Kawauchi;Tomoko Furuay;T. Uchiyama;A. Adachi;Takae Okada;Motonao Nakao;A. Oga;Kenichiro Uchida;K. Sasaki

Loss of 6q or 8p23 is associated with the total number of DNA copy number aberrations in adenoid cystic carcinoma

6q 或 8p23 缺失与腺样囊性癌中 DNA 拷贝数畸变总数相关

• DOI: 10.3892/or.2011.1446
• 发表时间: 2011
• 期刊: Oncol Rep
• 影响因子: 4.2
• 作者: Oga A;Uchida K;Nakao M;Kawauchi S;Furuya T;Chochi Y;Ikemoto K;Okada T;Ueyama Y;Sasaki K;Yousefpour F
• 通讯作者: Yousefpour F

DNA copy number aberrations associated with the clinicopathological features of colorectal cancers: Identification of genomic biomarkers by array-based comparative genomic hybridization

• DOI: 10.3892/or.2011.1246
• 发表时间: 2011-06-01
• 期刊: ONCOLOGY REPORTS
• 影响因子: 4.2
• 作者: Nakao, Motonao;Kawauchi, Shigeto;Sasaki, Kohsuke
• 通讯作者: Sasaki, Kohsuke