Bioimaging of tumor markers using both engineered lectins and antibodies
Bioimaging of tumor markers using both engineered lectins and antibodies
批准号:
21390173
负责人:
YAMAMOTO Kazuo
金额:
$12.48万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
It is crucial to identify biomarkers that are highly selective and sensitive in the diagnosis of cancers. We aimed to make a diagnosis platform using both antibodies and engineered lectins for detecting increased glycoprotein expression and alteration of sugar moieties accompanied with tumor progression, respectively. Two kinds of methods were applied to screen engineered lectins from randomly substituted lectin library, and several clones specific for tumor-associated glyco-antigens were obtained. Some cancer cells and specimens clearly stained with Fc-fusion proteins of these engineered lectins, which indicated that it would be a selective tool for diagnosis along with a specific antibody.
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DOI:
10.1091/mbc.e11-03-0201
发表时间:
2011-10
期刊:
Molecular biology of the cell
影响因子:
3.3
作者:
[Chen Y, Hu D, Yabe R, Tateno H, Qin SY, Matsumoto N, Hirabayashi J, Yamamoto K]
通讯作者:
Yamamoto K
Tumor cells of non-haematopoietic and haematopoietic origins express acivation-induced C-type lectin, the ligand for killer cell lectin-like receptor Fl.
非造血和造血来源的肿瘤细胞表达激活诱导的C型凝集素,其是杀伤细胞凝集素样受体F1的配体。
DOI:
--
发表时间:
2010
期刊:
Int.Immunol.
影响因子:
--
作者:
[Akatsuka A., et al]
通讯作者:
et al
Huaman XTP3-B binds to al-antitrypsin variant null Hong Kong via the C-terminal MRH domain in a glycan-dependent manner
Huaman XTP3-B 通过 C 端 MRH 结构域以聚糖依赖性方式与 al-抗胰蛋白酶变体 null Hong Kong 结合
DOI:
--
发表时间:
2010
期刊:
Glycobiology 20
影响因子:
--
作者:
[Yamaguchi D., et al.]
通讯作者:
et al.
The sugar-binding ability of human OS-9 and its involvment in ER-associated degradation
人 OS-9 的糖结合能力及其参与 ER 相关降解
DOI:
--
发表时间:
2010
期刊:
Glycobiology 20
影响因子:
--
作者:
[Mikami K., et al.]
通讯作者:
et al.
DOI:
10.1093/glycob/cwp175
发表时间:
2010-03-01
期刊:
GLYCOBIOLOGY
影响因子:
4.3
作者:
[Mikami, Kaoru, Yamaguchi, Daisuke, Yamamoto, Kazuo]
通讯作者:
Yamamoto, Kazuo
共 7 条
Exploring a molecular mechanism governing the metabolism to repress cancer progression depending on genetic backgrounds
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项目类别:Grant-in-Aid for Scientific Research (C)
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Elucidation of the molecular mechanism of Fmr1-associated premature ovarian failure based on novel protein-protein interactions
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Dissecting the roles of metabolism in the development of cancer by means of the mitochondrial hyperactive model mice
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批准号:26640082
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Lightning to a wind turbine in a wind farm and its influence on damages
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批准号:26420256
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财政年份:2014
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Regulation of nuclear protein functions by N-acetylglucosamine modification
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批准号:24390015
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.9万
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财政年份:2012
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A novel method to identify nuclear proteins modified with N-acetylglucosamine by using a soluble glycosyltransferase having nuclear-localization signal
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批准号:24659026
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
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财政年份:2012
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负责人:YAMAMOTO Kazuo
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Lightning Protections for Power, communication and control equipment in and in the vicinity of a wind turbine
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批准号:23760274
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.41万
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财政年份:2011
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依托单位:
Study of super ferromagnetism formed in a self-assembled film of magnetic nanoparticles
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批准号:23710140
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.91万
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财政年份:2011
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The collapse of the mechanisms which stably maintain M phase chromosome and its biological effect
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批准号:19310034
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$13.31万
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财政年份:2007
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负责人:YAMAMOTO Kazuo
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依托单位:
Mechanism of glycoprotein sorting and transport in the cells and its application for drug design
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批准号:16390019
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.47万
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财政年份:2004
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依托单位:
Origin of mutations in haploid and diploid organisms
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批准号:16310034
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.18万
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财政年份:2004
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依托单位:
Proteome Analysis for Early Diagnosis of Prion Disease
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批准号:14370796
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.87万
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财政年份:2002
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负责人:YAMAMOTO Kazuo
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依托单位:
Risk evaluation of particle-bound polycyclic aromatic hydrocarbons (pPAHs) at roadside air environment in Bangkok by time-series analysis and its application to urban traffic management
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批准号:14404007
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.42万
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财政年份:2002
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负责人:YAMAMOTO Kazuo
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依托单位:
A new glycome analysis by changing carbohydrate-binding specificities of cargo receptors in the cells
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批准号:13470485
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.22万
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财政年份:2001
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负责人:YAMAMOTO Kazuo
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Microbial structure and its control method for upgrading MBR
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批准号:13450213
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.56万
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财政年份:2001
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负责人:YAMAMOTO Kazuo
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依托单位:
Molecular Mechanisms of Radiation-Resistance in Deinococcus radiodurans
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批准号:12480152
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.41万
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财政年份:2000
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负责人:YAMAMOTO Kazuo
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依托单位:
Expression of cargo receptor ERGIC-53 with defferernt sugar-binding specificities and the effect on carbohydrate structures attached on secretory and membrane proteins.
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批准号:11557178
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$3.46万
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财政年份:1999
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负责人:YAMAMOTO Kazuo
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依托单位:
Evaluation systems for individual sensitivity against ultraviolet light using one hair alone
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批准号:11558067
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.83万
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财政年份:1999
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负责人:YAMAMOTO Kazuo
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依托单位:
Construction of cyborg lectins by using lambda foo phage display system, and structural analyses of the lectins complexed with sugars.
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批准号:10672038
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.22万
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财政年份:1998
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负责人:YAMAMOTO Kazuo
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依托单位:
DEVELOPMENT OF COMPREHENSIVE EVALUATION ANALYTICAL METHOD FOR CONSTRUCTION OF URBAN WATER RECYCLE SYSTEM
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批准号:09558074
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$5.82万
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财政年份:1997
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负责人:YAMAMOTO Kazuo
-
依托单位:
海外基金