课题基金 / 基金详情

Bioimaging of tumor markers using both engineered lectins and antibodies

Bioimaging of tumor markers using both engineered lectins and antibodies
使用工程凝集素和抗体对肿瘤标志物进行生物成像
批准号:
21390173
负责人:
YAMAMOTO Kazuo
金额:
$12.48万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

项目摘要

项目成果

YAMAMOTO Kazuo的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
It is crucial to identify biomarkers that are highly selective and sensitive in the diagnosis of cancers. We aimed to make a diagnosis platform using both antibodies and engineered lectins for detecting increased glycoprotein expression and alteration of sugar moieties accompanied with tumor progression, respectively. Two kinds of methods were applied to screen engineered lectins from randomly substituted lectin library, and several clones specific for tumor-associated glyco-antigens were obtained. Some cancer cells and specimens clearly stained with Fc-fusion proteins of these engineered lectins, which indicated that it would be a selective tool for diagnosis along with a specific antibody.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
DOI: 10.1091/mbc.e11-03-0201
发表时间: 2011-10
期刊: Molecular biology of the cell
影响因子: 3.3
作者: [Chen Y, Hu D, Yabe R, Tateno H, Qin SY, Matsumoto N, Hirabayashi J, Yamamoto K]
通讯作者: Yamamoto K
Tumor cells of non-haematopoietic and haematopoietic origins express acivation-induced C-type lectin, the ligand for killer cell lectin-like receptor Fl.
非造血和造血来源的肿瘤细胞表达激活诱导的C型凝集素,其是杀伤细胞凝集素样受体F1的配体。
DOI: --
发表时间: 2010
期刊: Int.Immunol.
影响因子: --
作者: [Akatsuka A., et al]
通讯作者: et al
Huaman XTP3-B binds to al-antitrypsin variant null Hong Kong via the C-terminal MRH domain in a glycan-dependent manner
Huaman XTP3-B 通过 C 端 MRH 结构域以聚糖依赖性方式与 al-抗胰蛋白酶变体 null Hong Kong 结合
DOI: --
发表时间: 2010
期刊: Glycobiology 20
影响因子: --
作者: [Yamaguchi D., et al.]
通讯作者: et al.
The sugar-binding ability of human OS-9 and its involvment in ER-associated degradation
人 OS-9 的糖结合能力及其参与 ER 相关降解
DOI: --
发表时间: 2010
期刊: Glycobiology 20
影响因子: --
作者: [Mikami K., et al.]
通讯作者: et al.
7
    Exploring a molecular mechanism governing the metabolism to repress cancer progression depending on genetic backgrounds
    • 批准号:
      18K07235
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.83万
    • 财政年份:
      2018
    • 负责人:
      YAMAMOTO Kazuo
    • 依托单位:
    Elucidation of the molecular mechanism of Fmr1-associated premature ovarian failure based on novel protein-protein interactions
    • 批准号:
      16K15709
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.16万
    • 财政年份:
      2016
    • 负责人:
      YAMAMOTO Kazuo
    • 依托单位:
    Dissecting the roles of metabolism in the development of cancer by means of the mitochondrial hyperactive model mice
    • 批准号:
      26640082
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.5万
    • 财政年份:
      2014
    • 负责人:
      YAMAMOTO Kazuo
    • 依托单位:
    Lightning to a wind turbine in a wind farm and its influence on damages
    • 批准号:
      26420256
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.83万
    • 财政年份:
      2014
    • 负责人:
      YAMAMOTO Kazuo
    • 依托单位:
    海外基金