Screening and gene analysis for the protection from muscle damage by statin drugs
Screening and gene analysis for the protection from muscle damage by statin drugs
批准号:
21390179
负责人:
SEISHIMA Mitsuru
金额:
$12.15万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2012
中文摘要
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英文摘要
We determined Ca2+increase in CD19+ cells by FCM. Rosuvastatin user patients with CK elevation showed a significant increase in Ca2+ within CD19+ cells compared with that in patients without CK elevation. Out of 18 patients with an elevated Ca2+, we found out one case with a mutation in exon 34 in RyR1 gene and two cases with amutation in exon 4 in CPTII gene. These findings show that this method is useful for the screening of a mutation in genes that relate to Ca2+transport and for the prediction of muscle damage by statins.
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標準臨床検査医学
标准临床检验医学
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[ベナー聖子, 掛山正心, 遠山千春, 高木 康(編集)]
通讯作者:
高木 康(編集)
DOI:
--
发表时间:
2012
期刊:
Curr Neurovasc Res
影响因子:
2.1
作者:
[Koinuma J, Akiyama H, Fujita M, Hosokawa M, Tsuchiya E, Kondo S, Nakamura Y, Daigo Y, Kimura A]
通讯作者:
Kimura A
Is the measurement of Ca2+-release inCD19+ B cells stimulated by statin useful for prediction of muscle damage as a side effect?
测量他汀类药物刺激的 CD19 B 细胞中的 Ca2 释放是否有助于预测肌肉损伤的副作用?
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Mori I, Hattori T, Osawa Y, Kanamori H, Kajita K, Morita H, Ishizuka T, Saito K, Ito H, Seishima M]
通讯作者:
Seishima M
DOI:
10.1096/fj.10-168351
发表时间:
2011-04
期刊:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
影响因子:
--
作者:
[Osawa Y, Seki E, Kodama Y, Suetsugu A, Miura K, Adachi M, Ito H, Shiratori Y, Banno Y, Olefsky JM, Nagaki M, Moriwaki H, Brenner DA, Seishima M]
通讯作者:
Seishima M
病理学入門
病理学导论
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Naito Y, Lee M-C, Kato Y, Nagai R, Yonei Y, 大滝純司, 西村亮, 赤池昭紀, 清島]
通讯作者:
清島
共 35 条
The role of IDO in the HBV-related liver diseases.
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批准号:24659361
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
-
财政年份:2012
-
负责人:SEISHIMA Mitsuru
-
依托单位:
Study on analytical system for the etiology of autoimmune disease using two-dimensional nano LC/MS
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批准号:17390161
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.93万
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财政年份:2005
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负责人:SEISHIMA Mitsuru
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依托单位:
Study on the mechanism of atherosclerotic lesion formation using cytokine-knockout mouse
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批准号:13470517
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.7万
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财政年份:2001
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负责人:SEISHIMA Mitsuru
-
依托单位:
The method for determination of serum lipid-free apolipoprotein concentration and its clinical application
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批准号:11557204
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$6.91万
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财政年份:1999
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负责人:SEISHIMA Mitsuru
-
依托单位:
The mechanism for synthesis and secretion of apo A-IV in CaCo-2 cells
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批准号:09672353
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.86万
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财政年份:1997
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负责人:SEISHIMA Mitsuru
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依托单位:
Study on apo A-IV polymorphism in patients with hyperlipidemia.
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批准号:07672485
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.22万
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财政年份:1995
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负责人:SEISHIMA Mitsuru
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依托单位:
海外基金