Screening and gene analysis for the protection from muscle damage by statin drugs

点击翻译按钮获取中文摘要

We determined Ca2+increase in CD19+ cells by FCM. Rosuvastatin user patients with CK elevation showed a significant increase in Ca2+ within CD19+ cells compared with that in patients without CK elevation. Out of 18 patients with an elevated Ca2+, we found out one case with a mutation in exon 34 in RyR1 gene and two cases with amutation in exon 4 in CPTII gene. These findings show that this method is useful for the screening of a mutation in genes that relate to Ca2+transport and for the prediction of muscle damage by statins.