Analyses of the development of liver cancer and cirrhosis by using cytoglobin-deficient mice

为了澄清细胞球蛋白（Cygb）在体内的分子功能，我们已经产生了Cygb-deficient mice。二乙基硝基胺的管理（25 ppm）在所有恶性肿瘤（肝脏癌症和Hemangioma）中的发展中受到抑制，由聚合物的累积和α-fetoprotein、介素-1 β和转化生长因子-β中的转化。基于这些发现，我们结合了Cygb-deficiency触发器对氧化物压力的调节和加速肝脏的肿瘤起源。Cygb是一种新型的肿瘤抑制剂。

To clarify the molecular function of cytoglobin(Cygb) in vivo, we generated Cygb-deficient mice. Administration of diethylnitrosamine(25 ppm) induced the development of liver tumors(liver cancer and hemangioma) in all of the Cygb-deficient mice, which were accompanied by the accumulation of collagen and the increased mRNA expression of α-fetoprotein, interleukin-1β, and transforming growth factor-β・in the liver. Based on these findings, we concluded that Cygb-deficiency triggers dysregulation of oxidative stress and accelerates tumorigenesis of the liver. Cygb is a novel tumor-suppressor.