Mechanisms of cardiovascular-renal connection on life-style diseases
Mechanisms of cardiovascular-renal connection on life-style diseases
批准号:
21390259
负责人:
ITO Sadayoshi
金额:
$11.48万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Present study determined the mechanisms of cardiovascular renal injury in CKD and the role of MG. 1%MG in drinking water was administered to Dahl salt sensitive rats exhibited increase in blood pressure associated with cardiovascular-renal injury. Cerebrovascular renal injury was observed in high salt fed stroke-prone spontaneously hypertensive rats, which was associated with blood pressure and oxidative stress. Glucose induced mitochondrial oxidative stress was observed in the tubules of juxtamedullary nephron, which was inhibited in glyoxalase 1 trangenic rats, indicating that carbonyl stress is responsible for glucose mediated renal injury
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腎髄質循環と血圧調整に対する酸化ストレスの役割
氧化应激对肾髓循环和血压调节的作用
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Sakamaki Y, Sakatsume M, Wang X, Inomata S, Yamamoto T, Gejyo F, Narita I, Nangaku, 森建文]
通讯作者:
森建文
若年高血圧における尿中酸化/カルボニルストレスおよび炎症マーカーの確立
青少年高血压尿氧化/羰基应激和炎症标志物的建立
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Suzuki M, Fujita T, et al., 森建文]
通讯作者:
森建文
Strain Vessel : New hypothesis for the cardiorenal syndrome
应变血管:心肾综合征的新假说
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Kato N, Yuzawa Y, Kosugi T, Hobo A, Sato W, Miwa Y, Sakamoto K, Matsuo S, Kadomatsu K., Sadayoshi Ito]
通讯作者:
Sadayoshi Ito
メチルグリオキサール(MG)の糖尿病合併症進展予測因子としての検討
甲基乙二醛(MG)检查作为糖尿病并发症进展的预测因子
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[森建文, 伊藤貞嘉]
通讯作者:
伊藤貞嘉
腎障害と尿酸
肾脏损伤和尿酸
DOI:
--
发表时间:
2011
期刊:
血圧
影响因子:
--
作者:
[Suzuki R, 他, 檜澤伸之, 伊藤貞嘉]
通讯作者:
伊藤貞嘉
共 57 条
Exploration of specific biomarkers for carbonyl stress inducible disease.
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批准号:24390211
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.65万
-
财政年份:2012
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负责人:ITO Sadayoshi
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依托单位:
Role of amine-carbonyl reaction as a novel mechanism for renal disease
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批准号:22659164
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.07万
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财政年份:2010
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负责人:ITO Sadayoshi
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依托单位:
Empire, Nation-state and Region in Modern Western World.
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批准号:15320103
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.18万
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财政年份:2003
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负责人:ITO Sadayoshi
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依托单位:
Cardiorenal association
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批准号:15390264
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.54万
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财政年份:2003
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负责人:ITO Sadayoshi
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依托单位:
Mechanisms regulating glomerular hemodynamics
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批准号:12470208
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.96万
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财政年份:2000
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负责人:ITO Sadayoshi
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依托单位:
The Control of Glomerular hemodynamics and its significance in renal dysfunction and hypertension
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批准号:10470215
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.19万
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财政年份:1998
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负责人:ITO Sadayoshi
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依托单位:
Control of glomerular function by juxtaglomerular apparatus
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批准号:08044233
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$1.54万
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财政年份:1996
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负责人:ITO Sadayoshi
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依托单位:
Role of the juxtaglomerular apparatus in hypertension and progressive renal impairment
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批准号:08457283
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$5.38万
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财政年份:1996
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负责人:ITO Sadayoshi
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依托单位:
海外基金