Generation of pathological models for Parkinson's disease

为了了解帕金森病的病理，复制帕金森病症状的小鼠模型是必不可少的。然而，目前没有一种模型能够满足病理要求。本研究将基于帕金森病的病因，尝试建立一种新的NADH脱氢酶（泛醌）黄蛋白2,24kda （NDUFV2）敲除小鼠和家族性帕金森病致病基因PINK1敲除小鼠，并表现出线粒体功能障碍，这将为未来的研究提供有用的信息。

To understand the pathology of Parkinson's disease, mouse models that replicate Parkinson's disease symptoms are indispensable. However, currently none of the models are able to meet the pathological demands. The present study will attempt to create a novel NADH dehydrogenase(ubiquinone) flavoprotein 2, 24kDa(NDUFV2) knockout mouse and familial Parkinson's disease causative gene PINK1 knockout mouse that presents mitochondrial dysfunction, based on the cause of Parkinson's disease, which will be useful for future studies.