Generation of pathological models for Parkinson's disease

帕金森病病理模型的生成

• 批准号: 21390272
• 负责人: HATTORI Nobutaka
• 金额: $ 11.4万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390272/
• 关键词: パーキンソン病; モデルマウス; ミトコンドリア; ミトファジー; Parkin; PINK1; NDUFV2; MPTP; parkin; 呼吸能; ミトコンドリア膜電位; MEF; ATP; パーキンソン病(PD); 蛋白分解系; Mitophagy; IRP2; インスリン; TIRF; PINk1; slip rod test; ドーパミントランスポーター

To understand the pathology of Parkinson's disease, mouse models that replicate Parkinson's disease symptoms are indispensable. However, currently none of the models are able to meet the pathological demands. The present study will attempt to create a novel NADH dehydrogenase(ubiquinone) flavoprotein 2, 24kDa(NDUFV2) knockout mouse and familial Parkinson's disease causative gene PINK1 knockout mouse that presents mitochondrial dysfunction, based on the cause of Parkinson's disease, which will be useful for future studies.

要了解帕金森氏症的病理，复制帕金森氏症症状的小鼠模型是必不可少的。然而，目前所有的模型都不能满足病理要求。本研究试图根据帕金森病的病因，建立一种新型的NADH脱氢酶(泛醌)黄素蛋白2，24 kDa(NDUFV2)基因敲除小鼠和家族性帕金森病致病基因PINK1基因敲除小鼠，该小鼠存在线粒体功能障碍，这将对未来的研究有所帮助。

项目成果

Reversible cerebral vasoconstriction syndrome presenting as subarachnoid hemorrhage, reversible posterior leukoencephalopathy, and cerebral infarction

可逆性脑血管收缩综合征，表现为蛛网膜下腔出血、可逆性后部白质脑病和脑梗死

• 发表时间: 2011
• 期刊: Intern Med
• 作者: Kadowaki T;et al;Yamamoto T;山中宏二;Noda K
• 通讯作者: Noda K

パーキンソン病の治療:私の処方.ランチョンセミナ-5

帕金森病的治疗：我的处方。午餐研讨会-5

• 发表时间: 2010
• 作者: 曽根雅紀;岡澤均;鍋島陽一;服部信孝
• 通讯作者: 服部信孝

Exendin-4, a glucagon-like peptide-1 receptor agonist, provides neuroprotection in mice transient focal cerebral ischemia.

• DOI: 10.1038/jcbfm.2011.51
• 发表时间: 2011-08
• 期刊: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition

• DOI: 10.4161/auto.7.2.14074
• 发表时间: 2011-02-01
• 期刊: AUTOPHAGY
• 影响因子: 13.3
• 作者: Saiki, Shinji;Sasazawa, Yukiko;Hattori, Nobutaka
• 通讯作者: Hattori, Nobutaka

Parkinson's disease-related LRRK2 G2019S mutation results from independent mutational events in humans

• DOI: 10.1093/hmg/ddq081
• 发表时间: 2010-05-15
• 期刊: HUMAN MOLECULAR GENETICS
• 影响因子: 3.5
• 作者: Lesage, Suzanne;Patin, Etienne;Brice, Alexis
• 通讯作者: Brice, Alexis