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Roles of a novel kidney-specific prostaglandin(PG) transporter in local PG clearance in renal cortex and its pathological relevance

Roles of a novel kidney-specific prostaglandin(PG) transporter in local PG clearance in renal cortex and its pathological relevance
新型肾脏特异性前列腺素(PG)转运蛋白在肾皮质局部 PG 清除中的作用及其病理相关性
批准号:
21390264
负责人:
KANAI Yoshikatsu
金额:
$11.48万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
In renal cortex, prostaglandin E_2(PGE_2) is released from the macula densa of distal tubules and functions as an autacoid responsible for the regulation of tubuloglomerular feedback and renin release from the juxtaglomerular apparatus. However, the molecular mechanisms through which released PGE_2 is removed and PGE_2 signal is turned off have not been understood. By using knockout mice in which the gene for the novel prostaglandin-specific transporter OAT-PG is disrupted, this study has addressed the questions. The results in this study indicate that OAT-PG is the transporter responsible for the local prostaglandin clearance in renal cortex.
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