Signaling mechanisms of a novel-type transmembrane receptor 4F2hc

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To reveal the signaling mechanisms mediated by a single-membrane spanning protein 4F2hc upregulated on cellular activation and in cancer cells, we have analyzed molecular complexes involving 4F2hc, preformed comprehensive signaling-pathway analysis using phosphoproteomics and searched for proteins binding to the intracellular domain of 4F2hc. We have found that 4F2hc together with CD147 forms multimolecular complexes with several transporters, the stimulation of 4F2hc/ LAT1 complex activate mTOR pathway without acting on MAPK pathway and an intracellular domain binding protein mediates 4F2hc signaling.