Septin functions and autistic spectrum disorder/pervasive developmental disorders during neuronal development

Sept 14在发育中的大脑皮质的皮质板中强烈表达，表明其在发育障碍中的病理生理作用。因此，我们筛选了Sept 14和Sept 4的结合伴侣。亲和层析结合鸟枪LC-MS/MS显示，许多蛋白质在细胞骨架的调节功能与这些septins相互作用。我们专注于几个分子，其中参与神经元细胞迁移已被报道，如coffilin，drepletin和细丝蛋白。

Sept14 is strongly expressed in the cortical plate of developing cerebral cortex, suggesting its pathophysiological role in developmental disorders. We thus screened binding partners for Sept14 and Sept4. Affinity chromatography combined with shotgun LC-MS/MS revealed that many proteins functioning in the cytoskeleton regulation interact with these septins. We are focusing on several molecules, of which involvement in neuronal cell migration has been reported, such as coffilin, drebrin and filamin.