Septin functions and autistic spectrum disorder/pervasive developmental disorders during neuronal development

神经元发育过程中的 Septin 功能和自闭症谱系障碍/广泛性发育障碍

• 批准号: 21390318
• 负责人: NAGATA Koh-ichi
• 金额: $ 8.49万
• 依托单位: Institute for Developmental Research, Aichi Human Service Center
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390318/
• 关键词: 小児神経学; セプチン; 大脳皮質; 神経細胞; 発達障害; 蛋白質; シグナル伝達

Sept14 is strongly expressed in the cortical plate of developing cerebral cortex, suggesting its pathophysiological role in developmental disorders. We thus screened binding partners for Sept14 and Sept4. Affinity chromatography combined with shotgun LC-MS/MS revealed that many proteins functioning in the cytoskeleton regulation interact with these septins. We are focusing on several molecules, of which involvement in neuronal cell migration has been reported, such as coffilin, drebrin and filamin.

Sept 14在发育中的大脑皮质的皮质板中强烈表达，表明其在发育障碍中的病理生理作用。因此，我们筛选了Sept 14和Sept 4的结合伴侣。亲和层析结合鸟枪LC-MS/MS显示，许多蛋白质在细胞骨架的调节功能与这些septins相互作用。我们专注于几种分子，其中参与神经元细胞迁移已被报道，如coffilin，drepletin和细丝蛋白。

项目成果

Role of the Septin in neural cell migration during brain development

Septin 在大脑发育过程中神经细胞迁移中的作用

• 发表时间: 2011
• 作者: Koh-ichi Nagata;Tomoyasu Shinoda;Yoshiaki V. Nishimura;Hidenori Ito
• 通讯作者: Hidenori Ito

Dysbindin-1, a schizophrenia risk factor, regulates dendritic spine formation : Evidence supporting neurodevelopmental hypothesis.

Dysbindin-1 是一种精神分裂症危险因素，调节树突棘形成：支持神经发育假说的证据。

• 发表时间: 2010
• 作者: 秋元望;本多健治;牛島悠一;別府薫;高野行夫;野田百美;永田浩一
• 通讯作者: 永田浩一

Functional analysis of dysbindin, a schizophrenia risk factor, in dendritic spine formation

精神分裂症危险因素dysbindin在树突棘形成中的功能分析

• 发表时间: 2011
• 作者: 伊東秀記;森下理香;西村嘉晃;篠田友靖;岩本郁子;永田浩一
• 通讯作者: 永田浩一

Identification of the Rho effector Rhotekin as a novel host factor mediating hepatitis C virus replication through NS5B interaction.

鉴定 Rho 效应器 Rhotekin 作为通过 NS5B 相互作用介导丙型肝炎病毒复制的新型宿主因子。

• 发表时间: 2009
• 作者: Arora P;Basu A;Krishnan R;Nagata K and Kaushik-Basu N.
• 通讯作者: Nagata K and Kaushik-Basu N.

Septin 14 is involved in cortical neuronal migration via interaction with Septin 4.

• DOI: 10.1091/mbc.e09-10-0869
• 发表时间: 2010-04-15
• 期刊: Molecular biology of the cell
• 影响因子: 3.3
• 作者: Shinoda T;Ito H;Sudo K;Iwamoto I;Morishita R;Nagata K
• 通讯作者: Nagata K