Identification of Schizophrenia-susceptible Ep igenetic Marker Engraved by Environmental Factor

点击翻译按钮获取中文摘要

As a model of molecular mechanisms of susceptibility to schizophrenia, increased by e xposure to the environmental factors, including hypoxia and immune response, during neonatal period, DNA methylation patterns engraved by the neonatal exposures, and susta ined throughout the life were proposed, and the fo llowing research has been conducted. 1)Identification of DNA methylation patterns in human neuronal cell lines exposed to hypoxia. 2)Identification of epigenomic conditions in adult mice brain which were exposed to neonatal immune responses to viral infection. 3)Evaluation of epigenomic conditions of schizophrenic postmortem brains.