Novel radiation therapy with regulation of immune response

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The objective of this study is to develop novel effective radiation therapy(RT) based on Radiation Immunobiology. In addition to the induction of apoptosis, we investigate the secondary anti-tumor activity of ionizing radiation mediated by the immune response to the irradiated tumor and host. When RT was followed with cytotoxic T lymphocyte therapy(CTL), antitumor activity of CTLs was markedly enhanced by prior RT, because RT inhibited the recruitment of myeloid derived suppressor cells. We demonstrated that the regulation of anti-tumor immune response contributed to the improvement of RT.