Integrated research for respective role of cancer and microenvironment towards clinical application

癌症与微环境各自作用的综合研究及其临床应用

• 批准号: 21390360
• 负责人: YAMAMOTO Hirofumi
• 金额: $ 10.9万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390360/
• 关键词: 癌; 微小環境; 浸潤; 転移

(1) We reported OSNA-based diagnosis of lymph node metastasis of colorectal cancer in 2010, and Ministry of Health, Labour and Welfare permitted its usage in diagnosis.(2) We produced the C4. 4A specific antibody that recognizes only invasive cancer cells. We also found that C4. 4A promotes EMT.(3) We found that hypoxia-induced gene JMJD1A promotes EMT in colon cancer.(4) We found that carbonate apatite containing specific siRNA showed a tumor shrinkage when it is injected into the tail vein of nude mice.(5) We found inhibition of both VEGF and Ang2 led to a tumor shrinkage in nude mice.

(1)我们在2010年报道了基于OSNA的结直肠癌淋巴结转移的诊断，并得到了厚生劳动省的许可。(2)我们生产了C4。4只能识别侵袭性癌细胞的特异性抗体。我们还发现了C4。(3)我们发现低氧诱导基因JMJD1A促进结肠癌的EMT。(4)我们发现含有特异性siRNA的碳酸盐磷灰石注射到裸鼠尾静脉后，肿瘤缩小。(5)我们发现抑制血管内皮生长因子和血管紧张素转换酶2都能导致裸鼠肿瘤缩小。

项目成果

C4. 4A is associated with tumor budding and EMT of colorectal cancer

C4。

• 发表时间: 2012
• 期刊: Cancer Science
• 影响因子: 5.7
• 作者: Oshiro;Yamamoto H et al
• 通讯作者: Yamamoto H et al

Clinical application of molecular biological testing for detecting lymph node metastasis of colorectal cancer. 8th International Symposium on Minimal Residual Cancer

分子生物学检测在结直肠癌淋巴结转移检测中的临床应用

• 发表时间: 2011
• 作者: Matsuoka T;Yamamoto A;Hamamoto S;Sogawa E;Kageyama K;Miki Y;Yoshida A;Iguci T.;Hirofumi Yamamoto
• 通讯作者: Hirofumi Yamamoto

Hypoxia-inducible adrenomedullin in colorectal cancer

结直肠癌中缺氧诱导的肾上腺髓质素

• 发表时间: 2011
• 期刊: Anticancer Res
• 影响因子: 2
• 作者: Uemura M;Yamamoto H et al
• 通讯作者: Yamamoto H et al

PLOD2 induced under hypoxia is a novel prognostic factor for hepatocellular carcinoma after curative resection

• DOI: 10.1111/j.1478-3231.2011.02619.x
• 发表时间: 2012-01-01
• 期刊: LIVER INTERNATIONAL
• 影响因子: 6.7
• 作者: Noda, Takehiro;Yamamoto, Hirofumi;Nagano, Hiroaki
• 通讯作者: Nagano, Hiroaki

Clinical application of molecular biological testing for detecting lymph node metastasis of colorectal cancer

分子生物学检测结直肠癌淋巴结转移的临床应用

• 发表时间: 2011
• 作者: Hirofumi Yamamoto;et al
• 通讯作者: et al