Prospective isolation of pancreatic cancer cells with highly malignant phenotype and development of future individualized therapy
Prospective isolation of pancreatic cancer cells with highly malignant phenotype and development of future individualized therapy
批准号:
21390381
负责人:
TANAKA Masao
金额:
$11.23万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
We identified CD133 positive pancreatic cancer cells with high malignant potential. CD133 positive pancreatic cancer cells have strong invasive ability via SDF1-CXCR4 pathway. We also found that migration of CD105 positive pancreatic cancer cells was promoted by cancer-stromal interactions. Moreover, we clarified that collagen-internalization receptor CD280 was an important molecule for invasion of pancreatic cancer cells. We reduced the invasion of pancreatic cancer cells by knockdown of CD280. In the present study, we identified several molecules as promising therapeutic targets.
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Pancreatic Stellate Cells Promote Migration of CD105+ Pancreatic Cancer Cells
胰腺星状细胞促进 CD105 胰腺癌细胞的迁移
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Taipei, Taiwan]
通讯作者:
Taiwan
膵癌におけるCD133陽性細胞は、癌間質作用を介してより高い遊走・浸潤能を獲得する
胰腺癌中的CD133阳性细胞通过癌基质作用获得更高的迁移和侵袭能力
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[森山大樹, 大内田研宙, 水元一博, 崔林, 余俊, 江上拓哉, 藤田逸人, 佐藤典宏, 当間宏樹, 永井英司, 田中雅夫]
通讯作者:
田中雅夫
The Functional Heterogeneity of Pancreatic Cancer Cells and Surrounding Stromal Cells in Cancer-Stromal Interactions
胰腺癌细胞和周围基质细胞在癌症-基质相互作用中的功能异质性
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Ohuchida K., et al]
通讯作者:
et al
分子発現解析に基づく膵癌診断法とその意義 特集『膵癌に対するトランスレーショナルリサーチの展望』 膵臓
基于分子表达分析的胰腺癌诊断及其意义 专题:“胰腺癌转化研究展望” 胰腺
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[大内田研宙, 大塚隆生, 水元一博, 田中雅夫]
通讯作者:
田中雅夫
High EGFR mRNA Expression Level is a Prognostic Factor for Reduced Survival in Pancreatic Cancer after Gemcitabine-based Adjuvant Chemotherapy International Journal of Oncology
高 EGFR mRNA 表达水平是基于吉西他滨的辅助化疗后胰腺癌生存率降低的一个预后因素 International Journal of Oncology
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Hayato Fujita, Kenoki Ohuchida, Kazuhiro Mizumoto, Soichi Itaba, Tetsuhide Ito, Kohei Nakata, Jun Yu, Tadashi Kayashima, Akifumi Hayashi, Ryota Souzaki, Tatsuro Tajiri, Manabu Onimaru, Tatsuya Manabe, Takao Ohtsuka, Masao Tanaka]
通讯作者:
Masao Tanaka
共 16 条
A new strategy for improving the efficacy of the conventional therapy of pancreatic cancer by remodeling its microenvironment
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批准号:25670586
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
-
财政年份:2013
-
负责人:TANAKA Masao
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依托单位:
Identifying the leading cell for the invasion of pancreatic cancer
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批准号:24390318
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.65万
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财政年份:2012
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负责人:TANAKA Masao
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依托单位:
Establishment of therapy for individual based on diagnostic imaging by artificial virus
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批准号:23659655
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2011
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负责人:TANAKA Masao
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依托单位:
ANALYSES OF THE SIGNAL TRANSDUCTION OF NOVEL ANTI-ARTHRITIC FACTOR, FRP, AND ITS EFFECTS ON IMMUNE SYSTEM
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批准号:18591105
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.51万
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财政年份:2006
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负责人:TANAKA Masao
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依托单位:
Tailor-made NK4-gene therapy for pancreatic cancer using nano devise.
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批准号:16209040
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$31.95万
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财政年份:2004
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负责人:TANAKA Masao
-
依托单位:
A conceptual framework for the next generation of the supply chain management
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批准号:15530287
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.11万
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财政年份:2003
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负责人:TANAKA Masao
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依托单位:
Analysis and modeling of micro- or nano-scale structure and microcirculation of bone
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批准号:15086210
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$20.93万
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财政年份:2003
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负责人:TANAKA Masao
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依托单位:
Patient specific individual computational mechanics for diagnosis and treatment planning of temporomandibular joint disorder
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批准号:14380402
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.54万
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财政年份:2002
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负责人:TANAKA Masao
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依托单位:
Treatment of pancreatic cancer by HGF antagonist, NK4, through new drug delivery system. -Approach from bench to practice
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批准号:13470257
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.09万
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财政年份:2001
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负责人:TANAKA Masao
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依托单位:
Patient specific indibidual computational bio-mechanics of temporomandibular joint system and application to temporomandibular disorder examination
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批准号:12680830
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.43万
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财政年份:2000
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负责人:TANAKA Masao
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依托单位:
New strategy against pancteato-biliary carcinoma using NK4, a four-kringle antagonist of hepatocyte growth factor
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批准号:10470259
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$8.0万
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财政年份:1998
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负责人:TANAKA Masao
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依托单位:
Modeling of adaptive bone remodeling and its application to optimal design of structure/material system (Approach to multilevel structural system)
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批准号:10650088
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:1998
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负责人:TANAKA Masao
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依托单位:
Numerical analysis on the dynamics of communities for sessile colonial animals
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批准号:07640843
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.02万
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财政年份:1995
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负责人:TANAKA Masao
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依托单位:
Practical Study or Teaching at University
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批准号:01410007
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项目类别:Grant-in-Aid for General Scientific Research (A)
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资助金额:$4.22万
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财政年份:1989
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负责人:TANAKA Masao
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依托单位:
Development of High-Speed Video Cameras and Study on Dynamic Deformation Behavior of Materials
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批准号:01850027
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项目类别:Grant-in-Aid for Developmental Scientific Research (B).
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资助金额:$5.06万
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财政年份:1989
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负责人:TANAKA Masao
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依托单位:
Evaluation of intra-specific or inter-specific competition for T. lubrica by a bio-economical method.
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批准号:62540500
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.15万
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财政年份:1987
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负责人:TANAKA Masao
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依托单位:
海外基金