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Analysis and modeling of micro- or nano-scale structure and microcirculation of bone

骨的微米或纳米级结构和微循环的分析和建模

基本信息

批准号：
15086210
负责人：
TANAKA Masao
金额：
$ 20.93万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15086210/
关键词：
Biomechanics Bone Microstructure

项目摘要

Bone, major component of skeletal system, is blood vessel-rich tissue, and the bone tissue structure is not only of structural architecture but also of vascular network for bone circulation. In this study, the microstructure of bone is analyzed from the viewpoints of the load bearing structure and of the vascular network of microcirculation. The network structure consisting of Haversian canal Volkmann's canal in cortical bone was analyzed by using radiation synchrotron CT, and the biphasic structural change of canal network was revealed in the cortical bone of growing rats tibiae. It was also found that the rarefaction of the canal network was enhanced by the disuse-mediated load reduction. The X-ray diffraction analysis and Vickers hardness test for trabeculae showed that the macroscopic anisotropy of cancellous bone was coming from the structural anisotropy of trabecular network structure and from the orientation dependent property of trabeculae as well. The material and mechanical properties of cortical bone was examined using nano-indentation test and FTIR microscopy, and much importance of bone quality is demonstrated in cortical bone of mature rats. A technique was established for the direct blood flow measurement of periosteal microcirculation by using the pensile-type CCD video microscope. The material transport in cortical bone through the blood vessel in canal network and the lacuno-canalicular system in bone matrix was modeled in terms of the convective diffusion in tubes and the diffusion in homogenized continuum, and the physiological material concentration was analyzed based on the canal network structure of cortical bone. Simulation model of bone remodeling for physiological window was extended to a unified model involving models of the osteocyte apoptosis for disuse window and the targeted remodeling for overuse windows, and its capability was examined through a couple of simulation studies.

骨是骨骼系统的主要组成部分，是富含血管的组织，骨组织结构不仅具有结构构筑性，而且还具有骨循环的血管网络。本研究从承重结构和微循环血管网络的角度分析了骨的微观结构。用同步辐射CT对皮质骨内由哈弗管和Volkmann管组成的网状结构进行了分析，揭示了生长期大鼠胫骨皮质骨管网状结构的双相变化。研究还发现，弃用介导的负荷减少增强了渠网的稀疏性。骨小梁的X射线衍射分析和维氏硬度测试表明，松质骨的宏观各向异性既来自于骨小梁网络结构的结构各向异性，也来自于骨小梁的取向依赖性。利用纳米压痕试验和傅里叶变换红外光谱对皮质骨的材料和力学性能进行了测试，结果表明成年大鼠皮质骨的骨质量具有重要意义。建立了一种利用悬挂式CCD视频显微镜直接测量骨膜微循环血流量的技术。用管内对流扩散和均匀连续介质中的扩散来模拟材料在皮质骨中通过管网中的血管和骨基质中的腔隙系统的传输，并根据皮质骨的管网结构来分析生理性的材料浓度。将生理性窗的骨重建模拟模型扩展为包括废弃窗的骨细胞凋亡模型和过度使用窗的靶向重建模型的统一模型，并通过几个模拟研究验证了该模型的有效性。

项目成果

期刊论文数量（82）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Note on Anisotropic Properties of Cancellous Bone and Trabeculae : Elasticity and Hardness

关于松质骨和小梁各向异性特性的注释：弹性和硬度

DOI：
发表时间：
2004
期刊：
Biomechanics at Micro- and Nano-scale Levels (World Scientific) 1
影响因子：
0
作者：
寺村聡;富田直秀;原田恭治;闕上凱;前北渉;安達泰治;鈴木基史;T.Sakamoto;Masao Tanaka
通讯作者：
Masao Tanaka

Relationship between mechanical property of cancellous bone and hardness of trabeculae

DOI：
10.1299/jsmec.47.1075
发表时间：
2004-12-01
期刊：
JSME INTERNATIONAL JOURNAL SERIES C-MECHANICAL SYSTEMS MACHINE ELEMENTS AND MANUFACTURING
影响因子：
0
作者：
Todoh, M;Ihara, M;Tanaka, M
通讯作者：
Tanaka, M

Biomechanics at Micro- and Nanoscale levels. Vol. I

微米和纳米级的生物力学。