Development of the new approach for cardiac repair by enhancing endogenous regeneration

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Recent studies show that cardiac stem cells and mitotic cardiomyocytes have been identified in the failing and infracted hearts, suggesting that the heart may have regenerative potential. Substantial recovery of cardiac function by the implantation of a left ventricular assist device(LVAD) was found in some patients with heart failure. We speculate that reduction in mechanical stress achieved by LVAD support promotes cardiac regeneration by improving local environment. This study shows that reduction in mechanical stress assists the regeneration of the injured hearts. Furthermore, our findings suggest that mechanical stress suppresses the growth of cardiac stem cells, increases their release of the angiogenic factors, and enhances their myogenic differentiation.