Development of the new approach for cardiac repair by enhancing endogenous regeneration

通过增强内源性再生开发心脏修复新方法

• 批准号: 21390391
• 负责人: MIKAMO Akihito
• 金额: $ 10.73万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390391/
• 关键词: 心筋再生; メカニカルストレス; 再生医療; 幹細胞

Recent studies show that cardiac stem cells and mitotic cardiomyocytes have been identified in the failing and infracted hearts, suggesting that the heart may have regenerative potential. Substantial recovery of cardiac function by the implantation of a left ventricular assist device(LVAD) was found in some patients with heart failure. We speculate that reduction in mechanical stress achieved by LVAD support promotes cardiac regeneration by improving local environment. This study shows that reduction in mechanical stress assists the regeneration of the injured hearts. Furthermore, our findings suggest that mechanical stress suppresses the growth of cardiac stem cells, increases their release of the angiogenic factors, and enhances their myogenic differentiation.

最近的研究表明，在衰竭和梗塞的心脏中发现了心脏干细胞和有丝分裂心肌细胞，这表明心脏可能具有再生潜力。通过植入左心室辅助装置（LVAD），一些心力衰竭患者的心功能得到了显着恢复。我们推测，LVAD 支持减少机械应力可通过改善局部环境促进心脏再生。这项研究表明，机械应力的减少有助于受伤心脏的再生。此外，我们的研究结果表明，机械应力抑制心脏干细胞的生长，增加其血管生成因子的释放，并增强其肌原性分化。

项目成果

Mechanical stress suppresses the proliferation and improves the differentiation of cardiac stem cells and increases the release of paracrine factors

机械应力抑制增殖并改善心脏干细胞的分化并增加旁分泌因子的释放

• 发表时间: 2012
• 作者: Kurazumi H;Li TS;Kubo M;Takemoto Y;Ohshima M;Mikamo A;Hamano K
• 通讯作者: Hamano K

The effects of mechanical stress on the growth, differentiation, and paracrine factor production of cardiac stem cells.

• DOI: 10.1371/journal.pone.0028890
• 发表时间: 2011
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Kurazumi H;Kubo M;Ohshima M;Yamamoto Y;Takemoto Y;Suzuki R;Ikenaga S;Mikamo A;Udo K;Hamano K;Li TS
• 通讯作者: Li TS

メカニカルストレスが心筋幹細胞へ及ぼす影響

机械应力对心脏干细胞的影响

• 发表时间: 2011
• 作者: 藏澄宏之;李桃生;工藤智明;鈴木亮;久保正幸;池永茂;白澤文吾;美甘章仁;濱野公一
• 通讯作者: 濱野公一

Identification of Risk Factors Related to Poor Angiogenic Potency of Bone Marrow Cells From Different Patients

• DOI: 10.1161/circulationaha.108.837039
• 发表时间: 2009-09-15
• 期刊: CIRCULATION
• 影响因子: 37.8
• 作者: Li, Tao-Sheng;Kubo, Masayuki;Hamano, Kimikazu
• 通讯作者: Hamano, Kimikazu

Ischemic Pre-Conditioning Enhances the Mobilization and Recruitment of Bone Marrow Stem Cells to Protect Against Ischemia/Reperfusion Injury in the Late Phase

• DOI: 10.1016/j.jacc.2009.02.015
• 发表时间: 2009-05-12
• 期刊: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
• 影响因子: 24
• 作者: Kamota, Takahiro;Li, Tao-Sheng;Hamano, Kimikazu
• 通讯作者: Hamano, Kimikazu