Developmental research on novel brain tumor therapy using recombinant oncolytic herpes viruses

点击翻译按钮获取中文摘要

We performed a developmental research on recombinant oncolytic viruses that possess certain antitumor functions and are useful for brain tumor therapy. A third-generation oncolytic herpes simplex virus type 1(G47.) was used as the backbone to insert foreign sequences. Oncolytic viruses that express immune-stimulatory factors or luciferase, or that use tumor-specific promoters, were constructed and evaluated, and proved to be highly useful. G47. is expected as a new drug for brain tumors in the near future, and a progress has been made in the basic development of next generation onoclytic virus therapy.