Development of perioperative cerebral monitoring system using near-infrared time-resolved spectroscopy

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The purpose of this study is the development of the quantitative measurement of the cerebral cyt. aa3 by near-infrared time-resolved spectroscopy(TRS). Firstly, the algorithms of the redox state of cyt. aa3 in 3-wavelength or 6-wavelength TRS system were developed by the absorption coefficient values of oxy-and deoxy-Hb, which were obtained by the study of blood phantom models. Furthermore, the algorithms in 3-wavelength or 6-wavelength TRS system were evaluated by the dog model with cardiopulmonary bypass or the pig model with cardiac arrest. We concluded that the algorithms in 6-wavelength TRS system rather than 3-wavelength are capable of reliably measuring changes in the redox state of cerebral cyt. aa3 during severe conditions such as cardiac arrest.