Investigation on molecular biological mechanism of diurnal micturition rhythm

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We discovered circadian oscillation of Connexin43(Cx43), a molecule controlling functional bladder capacity, is regulated thorough interaction by Rev-erbα, a gene related with the circadian clock, and Sp-1, a molecule unrelated with the clock. As a result, circadian rhythm is generated in gap junction activity among bladder smooth muscle cells and contributes to micturition rhythm, with bladder capacity larger during sleep phase than during active phase. Thus, circadian clock is a regulator of micturition rhythm.