Basic and developmental research of a novel anti-tumor protein with dendritic cell-inducible activity.

具有树突状细胞诱导活性的新型抗肿瘤蛋白的基础和开发研究。

• 批准号: 21390441
• 负责人: NASU Yasutomo
• 金额: $ 9.15万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390441/
• 关键词: REIC/Dkk-3; 前立腺癌; 腎細胞癌; 抗癌免疫; 樹状細胞; REIK/DKK-3; サイトカイン; REIC; 遺伝子治療; 蛋白治療.; ノックアウトマウス

The REIC/Dkk-3 gene has been reported to be a tumor suppressor and the expression is significantly downregulated in a broad range of cancer cell types. In this study, we focused the REIC protein and clarified the immunological anti-cancer function and the possible utility for the clinical use. We believe that current findings are available to create innovative cancer-targeting and immunological therapy for the cancer diseases including prostate cancer.

据报道，REIC/Dkk-3基因是一种肿瘤抑制基因，其表达在广泛的癌细胞类型中显著下调。本研究对REIC蛋白进行了深入研究，阐明了其免疫抗癌功能及其临床应用的可能性。我们相信，目前的研究结果可用于创建创新的癌症靶向和免疫治疗的癌症疾病，包括前列腺癌。

项目成果

Preclinical safety and efficacy of in situ REIC/Dkk-3 gene therapy for prostate cancer.

• DOI: 10.18926/amo/48076
• 发表时间: 2012-03
• 期刊: Acta medica Okayama
• 影响因子: 0.5
• 作者: Keiichiro Kawauchi;Masami Watanabe;H. Kaku;Peng Huang;Kasumi Sasaki;M. Sakaguchi;K. Ochiai;N. Huh;Y. Nasu;H. Kumon

Single nucleotide polymorphism WRN Leu1074Phe is associated with prostate cancer susceptibility in Chinese subjects.

• 发表时间: 2011-10
• 期刊: Acta medica Okayama
• 影响因子: 0.5
• 作者: Lei Wang;H. Kaku;P. Huang;Kexin Xu;Kai-Ying Yang;Jiheng Zhang;Ming Li;Liping Xie;Xiao-feng Wang;Akiko Sakai;Masami Watanabe;Y. Nasu;K. Shimizu;H. Kumon;Y. Na

A randomized phase II traial of personalized peptide vaccine plus low dose estramustin phosphate (EMP) versus standard dose EMP in patients with castration resistant prostate cancer

个性化肽疫苗联合低剂量雌莫司汀磷酸盐 (EMP) 与标准剂量 EMP 在去势抵抗性前列腺癌患者中的随机 II 期试验

• 发表时间: 2010
• 期刊: Cancer Immunol Immunother
• 作者: Noguchi M;et al
• 通讯作者: et al

Could salvage surgery after chemotherapy have clinical impact on cancer survival of patients with metastatic urothelial carcinoma?

• DOI: 10.1007/s10147-011-0350-z
• 发表时间: 2013-02-01
• 期刊: INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
• 影响因子: 3.3
• 作者: Bekku, Kensuke;Saika, Takashi;Kumon, Hiromi
• 通讯作者: Kumon, Hiromi

Down-regulation of BiP/GRP78 sensitizes resistant prostate cancer cells to gene-therapeutic overexpression of REIC/Dkk-3

• DOI: 10.1002/ijc.24764
• 发表时间: 2010-04-01
• 期刊: INTERNATIONAL JOURNAL OF CANCER
• 影响因子: 6.4
• 作者: Tanimoto, Ryuta;Sakaguchi, Masakiyo;Huh, Nam-Ho
• 通讯作者: Huh, Nam-Ho