Role of retinoic acid in the mechanism of skin wound healing

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We searched for a role of retinoic acid(RA) in the developmental skin using Cyp26b1 knockout(KO) mice. A skin barrier dysfunction was observed in the Cyp26b1-KO epidermis. We found malformation in the cornified layer and absence of keratohyaline granules in the granular layer. Krtap13, a marker of the periderm, was also up-regulated and last in later stages. Although the Cyp26b1-KO skin lacked hair follicles, skin grafting to a nude mouse could induce hair formation. We performed fetal operation to know the effect of RA on wound healing. In the Cyp26b1-KO skin, a delay of healing was seen compared with the normal one. In this study, we found RA is critical for skin development and wound healing.