Translational research of hard tissue regeneration using physiologically active substances

C型利钠肽（CNP）通过直接作用于软骨细胞，增加软骨细胞的大小和细胞外间隙，促进软骨内骨的生长。另外，CNP通过直接作用于成骨细胞而影响骨形成，成年牙髓和乳牙牙髓脱落间充质干细胞与骨髓间充质干细胞相比，成骨分化潜能高，肾上腺髓质素对成骨分化无影响。

C-type natriuretic peptide(CNP) promotes endchondral bone growth by acting chondrocytes directly to increase the size of chondrocytes and the space extracellular space. In addition, CNP affects bone formation by acting osteoblasts directly.Adult dental pulp and exfoliated deciduous teeth pulp-derived mesenchymal stem cells compared with bone marrow-derived mesenchymal stem cells, osteogenic differentiation potentials were high.Adrenomedullin didn' t affect on osteodifferentiation.