Isolation of molecules synthesized by stromal cells, which regulate tumor invasion and metastasis : application in diagnosis and therapy

为了评价基质成分在口腔鳞状细胞癌(SCC)细胞发展中的作用，我们研究了成纤维细胞对SCC细胞增殖、运动和蛋白分解活性的影响。口腔鳞状细胞癌间质中的成纤维细胞合成TSP-1，TSP-1诱导口腔鳞癌细胞向肝细胞迁移，增强其合成基质金属肽酶9(MMP9)的能力。成纤维细胞产生的I型胶原通过整合素αvβ8促进口腔鳞癌细胞的增殖和迁移

To assess the participation of stromal components in the progression of oral squamous cell carcinoma(SCC) cells, we investigated the effect of fibroblasts on the proliferation, motility and proteolytic activity of SCC cells. Fibroblasts in the stroma of oral SCC synthesize TSP-1, which induces haptotactic migration and enhances the ability to synthesize matrix metallopeptidase 9(MMP-9) in oral SCC cells. Further type I collagen produced by fibroblasts facilitates the proliferation and migration of oral SCC cells via integrinαvβ8