Study of the delivery system of nucleic acid medicines targeting cell adhesion molecules controlling the metastasis of oral cancer

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Transfection of squamous cell carcinoma (SCC) cells with a mammalian expression vector containing the cDNA for integrin alpha V in the antisense orientation reduced alpha V expression in SCC cells. Transfection with antisense oligonucleotides targeting integrin beta 8 reduced beta 8 expression in SCC cells. Suppression of integrin alpha V or beta 8 by transfection with antisense cDNA plasmid or antisense oligonucleotides led to a decrease in the proliferation and invasiveness of SCC cells. In addition, the downregulation of integrin alpha V or beta8 significantly reduced the tumorigenicity of oral SCC.