Exploration of regionality in laboratory test results and derivation of common reference intervals through international collaborative survey

2009年进行了一项关于参考值的国际多中心研究，东南亚有62个实验室参与。招募了3541名明确定义的健康个体（日本2082人;海外1459人）。在日本，对所有血清中的72种常用分析物进行了集体测量。在22种分析物中观察到检测结果的区域性，但当数据仅限于来自日本的数据时，则不存在区域性。基于生活方式问卷调查，分析了变异来源的各种证据。在取得成功成果后，计划并启动了一项全球规模的扩大研究，并于2011年制定了共同议定书。

An international multi-center study on reference values was conducted in 2009 with participation of 62 laboratories in South-east Asia. 3541 well-defined healthy individuals(Japan 2082 ; oversea 1459) were recruited. All sera were measured collectively for 72 commonly measured analytes in Japan. Regionality of test results was observed in 22 analytes, but it was not when data were limited to those from Japan. A variety of evidence on sources of variations was analyzed based on life style questionnaire. With successful outcome, an expanded study of a global scale was planned and launched with elaboration of common protocol in 2011.