Exploration of regionality in laboratory test results and derivation of common reference intervals through international collaborative survey

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An international multi-center study on reference values was conducted in 2009 with participation of 62 laboratories in South-east Asia. 3541 well-defined healthy individuals(Japan 2082 ; oversea 1459) were recruited. All sera were measured collectively for 72 commonly measured analytes in Japan. Regionality of test results was observed in 22 analytes, but it was not when data were limited to those from Japan. A variety of evidence on sources of variations was analyzed based on life style questionnaire. With successful outcome, an expanded study of a global scale was planned and launched with elaboration of common protocol in 2011.