Analysis of age-related variations in laboratory tests by use of latent information recovered from routine laboratory data

利用从常规实验室数据中恢复的潜在信息分析实验室测试中与年龄相关的变化

• 批准号: 13672437
• 负责人: ICHIHARA Kiyoshi
• 金额: $ 1.15万
• 依托单位: Yamaguchi University (2002)Kawasaki Medical School (2001)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13672437/
• 关键词: reference interval; disease-specific reference interval; age-related changes; latent reference value extraction method; data-mining; latent abnormal value exclusion method; standardization; 小児基準値; フタマイニング; 臨床検査; 基準個体; 多変量解析

I have developed a data-mining method to derive a reference interval (RI) for laboratory tests from a routine laboratory data, called "latent reference value extraction method", in 1996. It features simultaneous setting of RIs for multiple test items mutually related and a rigid exclusion of those individuals with abnormal values in other test items. Thus it requires an iterative processing to optimize RIs. In this research I developed a realistic algorithm to obtain appropriate initial estimates of RIs, to exclude apparently abnormal individuals, and to adjust for a distorted age distribution commonly seen in patients' population. A software based on the revised methodology not only has a flexible ability to optimize derivation of RIs but also has an ability to derive age-specific reference interval using a stepwise age-adjusted exclusion of abnormal values. The software was applied to various clinical laboratory data. In Okayama, age-related RIs were derived for common test items. Consistent age-related changes in RIs were observed in all the analytes. It was also applied to reveal year-by-year changes in RIs (0 to 23 year old) for major laboratory analytes. All of them showed peculiar profiles while a use of conventional methodology led to apparently distorted profiles. It was also found to be applicable to obtain so-called disease-specific RIs using a large data from hemodialysis patients.

本人于1996年开发了一种从常规实验室数据中提取参考区间的数据挖掘方法，称为“潜在参考值提取法”。它的特点是同时设置多个相互关联的测试项目的RI，并严格排除那些在其他测试项目中具有异常值的个体。因此，它需要迭代处理来优化RI。在这项研究中，我开发了一个现实的算法，以获得适当的初始估计的RI，排除明显异常的个人，并调整扭曲的年龄分布常见于患者的人口。一个软件的基础上修订的方法不仅具有灵活的能力，以优化推导的RI，但也有能力获得特定年龄的参考区间使用逐步年龄调整排除异常值。该软件应用于各种临床实验室数据。在冈山，针对常见测试项目推导出与年龄相关的RI。在所有分析物中均观察到一致的年龄相关RI变化。它还用于揭示主要实验室分析物的RI（0至23岁）的逐年变化。所有这些都显示出特殊的轮廓，而使用传统方法则导致明显扭曲的轮廓。还发现它适用于使用血液透析患者的大量数据获得所谓的疾病特异性RI。

项目成果

Itoh Y., Ichihara K.: "Standardization of immunoassay for CRM 470-relate d proteins in Japan: from evaluating CRM 470 to setting reference intervals."Clin. Chem. Lab. Med.. 39. 1052-1061 (2001)

Itoh Y.、Ichihara K.：“日本 CRM 470 相关 d 蛋白免疫测定的标准化：从评估 CRM 470 到设定参考区间。”

市原清志: "検査データを利用した基準個体の集め方"SRL宝函. 別冊. 49-62 (2002)

Kiyoshi Ichihara：“如何使用测试数据收集参考个体” SRL Hobako 单独卷。

Ichihara, K., Sato, K.: "Evidence-based laboratory interpretation system built on a large collection of case records with well-defined diagnosis"Clin Chem Labo Med.. 39. 1033-1044 (2000)

Ichihara, K.、Sato, K.：“基于大量病例记录并具有明确诊断的基于证据的实验室解释系统”Clin Chem Labo Med.. 39. 1033-1044 (2000)

Itho, Y.Ichihara, K.: "Standardization of immunoassay for CRM 470-related proteins in Japan : from evaluating CRM 470 to setting reference intervals"Clin Chem Labo Med. 39. 1054-1061 (2001)

Itho, Y.Ichihara, K.：“日本 CRM 470 相关蛋白免疫测定的标准化：从评估 CRM 470 到设定参考区间”Clin Chem Labo Med。

Ichihara K: "Derivation of age-specific reference interval from routine by a computer-intensive algorithm"Clin Chem Lab Med. Vol40. S55 (2002)

Ichihara K：“通过计算机密集型算法从常规中推导特定年龄的参考区间”Clin Chem Lab Med。