Rapid and large scale production system of virus-like hollow nano-particles using Escherichia Coli

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Envelope proteins of human hepatitis B virus form "virus-like hollow nao-particles(HBsAg-like partiles)" which are useful bio-material applicable to vaccines, carriers for diagnostic tests, and drug delivery systems. We established the production system of the particles by using Escherichia Coli as an expression system, and analyzed the resultant particles. As the results, this production system decreases the time and cost for the particle production and accelerates the development of new useful particles such as particles displaying recognition sequences for living substances.