权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

A research about development of new rehabilitation technique of motor function with brain magnetic stimulation in elder persons

脑磁刺激老年人运动功能康复新技术的研究

基本信息

批准号：
21500472
负责人：
TOUGE Tetsuo
金额：
$ 2.91万
依托单位：
Kagawa University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2009
资助国家：
日本
起止时间：
2009 至 2011
项目状态：
已结题

项目摘要

Objective : To evaluate the effects of training by transcranial magnetic stimulation(TMS) with maximum voluntary muscle contraction(MVC) for serial 4 days on motor neuron function in elder persons, motor evoked potentials(MEPs) and the maximum pinching muscle force were recorded sequentially.Methods : Four MEPs in the first digital interossei(FDI) muscle elicited by TMS during pinching a button-like strain-gauge transducer with maximum muscle force for 2 seconds were recorded before and at an each 15 minutes interval until 1 hour after starting the sessions(test condition). In a control condition, sham TMS was employed except that real TMS was delivered to record MEPs before and 1 hour after onsets of the sessions in Day 1 and 4.Results : MEP amplitudes or areas in FDI muscle and pinching muscle force were significantly increased after the sessions in the both conditions. Pinching muscle force tended to be significantly larger before starting the sessions from Day 2 to Day 4 in the test condition compared with the control condition. Changes of MEP sizes did not significantly differ between the groups.Conclusion : Although the present study suggests that daily TMS with MVC facilitates muscle power in elder persons, we need further studies to confirm this effect of TMS with MVC.

目的：为评价连续4d的经颅磁刺激（TMS）最大随意肌收缩（MVC）训练对老年人运动神经元功能的影响，记录运动诱发电位（MEP）和最大捏肌力。在捏按钮样应变过程中，TMS引起的第一指骨间（FDI）肌肉中的四个MEP-在开始训练之前和开始训练之后每隔15分钟记录具有最大肌肉力量2秒的测量传感器，直到1小时（测试条件）。在对照组中，于第1天和第4天分别于训练前和训练后1 h用真实的TMS记录MEP。结果：训练后，两组大鼠的FDI肌MEP幅值或面积及捏肌力均显著增加。与对照条件相比，试验条件下第2天至第4天的训练开始前，捏肌力往往显著更大。MEP大小的变化并没有显着差异groups.Conclusion：虽然目前的研究表明，每日TMS与MVC促进肌肉力量在老年人，我们需要进一步的研究来证实这种效果的TMS与MVC。