Investigation of Human Mechanism on Multimodal Perception/Memory andApplication to Early Diagnosis System for Dementia Disease

为了探讨人类多模态感知/记忆的机制及其在痴呆疾病早期诊断系统中的应用，本研究通过行为学、脑电和功能磁共振成像（fMRI）实验测量了人类视觉、听觉和触觉感知以及注意、记忆和语言等高级功能的特征。主要结果如下：视觉行为实验结果提示，当空间频率为0.053 ~ 0.084 cycle/deg，中央视野内视觉刺激的亮度较高时，视觉圆矢量（CV）更引人注目。我们利用光纤和接触式透镜研制了水平视角为120 °、垂直视角为120 °的宽视角功能磁共振视觉呈现系统。本文介绍了该系统的功能和性能，并报告了评价实验的结果.听觉实验结果表明，耳塞对声音定位的影响与耳塞的作用有关，耳塞对声音定位的影响与耳塞对声音定位的影响有关. 关于我们 我们开发了一种新型的自动触觉模式传递系统，该系统能够执行触觉认知和神经成像程序。结果表明，主动和被动触摸的性能取决于触觉模式的相似率。当标准角小于90°时，随着标准角的增大，人的抬高角辨别力增大。当标准角度大于90°时，提高的角度辨别能力处于同一水平;脑成像数据显示视觉空间注意和听觉空间注意存在部分重叠。此外，它还揭示了参与视觉空间注意与视觉时间注意表现的神经系统之间的部分重叠。本研究采用被动听力任务，通过对日本被试进行日语和英语单词和无意义单词的被动听力实验，研究了日本被试左额下回的功能分离，为痴呆的早期诊断系统的建立提供了基础资料。少

In order to investigate human mechanism on multimodal perception/memory and application to early diagnosis system for dementia disease, we have measured human characteristics on visual, auditory and tactile perception and attention, memory and language higher functions by behavior, EEG and fMRI experiments. The important results can summary as follows.The visual behavior experimental results may suggested that the visual circular vection (CV) to be more compelling when the spatial frequency from 0.053cycle/deg to 0.084 cycle/deg and high luminance of visual stimuli in central vision field. We developed the wide-view visual presentation system with a horizontal visual angle of 120 deg and a vertical angle of 120 deg using nonmagnetic optical fibers and contact lens for fMRI. In this paper, we introduce the functions and performance of this system and report the results of our evaluative experiment.Auditory experimental results suggested that the effect of the earplug on sound localizati … More on ability had two causes, sound insulation and spectral change.We developed a novel automatic tactile pattern delivery system that is capable of perform the tactile cognitive and neuroimaging procedures. The results indicated that the performance of active and passive touch depend on the similar rate of the tactile patterns. Human raised angle discrimination was increased as the standard angular was increased when the standard angular was smaller than 90°. The raised angle discrimination ability was at a same level, when the standard angular was larger than 90°.The brain-imaging data showed a partial overlap between visual spatial attention and auditory spatial attention. In addition, it revealed a partial overlap between the neural systems involved in the performance of visual spatial attention versus visual temporal attention. Function segregation in the left inferior frontal gyrus was investigated in an fMRI experiment using a passive listening task, in which Japanese subjects were required to passively listen to words and nonsense words in Japanese and English.The above basic research results providing basic dada to develop the early diagnosis system for dementia disease. Less