Temporal regulation of cortical neural precursor cell fate by polycomb group proteins

在新皮层发育过程中，神经前体细胞（npc或神经干细胞）依次产生各种类型的神经元和神经胶质细胞。尽管在这一顺序过程中命运转换的时间对于确定每种细胞类型的数量至关重要，但其机制尚不完全清楚。本课题的研究结果表明，多梳群复合体（PcG）限制了npc的能力。

During neocortical development, neural precursor cells (NPCs, or neural stem cells) produce various types of neurons and glial cells in a sequential manner. Although the timing of the fate switch during this sequential process is critical for determining the number of each cell type, the mechanisms are not fully understood. The results obtained in this project show that the polycomb group complex (PcG) restricts the competence of NPCs.