Functional analysis of nucleostemin in pluripotent stem and tissue stem cells
Functional analysis of nucleostemin in pluripotent stem and tissue stem cells
多能干细胞和组织干细胞中nucleostemin的功能分析
批准号：
21770242
负责人：
NAGAMATSU Go
金额：
$2.91万
依托单位：
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2009
资助国家：
日本
项目状态：
已结题
起止时间：
2009 至 2010
中文摘要
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英文摘要
We succeeded in making the conditional Nucleostemin deficient embryonic stem cells by a consecutive targeting of two times. Upon deletion of Nucleostemin allele, stop of proliferation and cell death had found. Moreover, it was clarified that the genes that did an important working to the maintenance of the undifferentiation of the embryonic stem cell, such as Oct3/4, Nanog, and Sox2 decreased along with the Nucleostemin loss. The possibility of the inducement or maintaining of the factors that Nucleostemin is related to the above-mentioned undifferentiated maintenance is suggested from this. On the other hand when Nucleostemin was over-expressed, the up-regulation of pluripotency associated genes was observed.
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会议论文
始原生殖細胞からの多能性幹細胞分化
从原始生殖细胞分化出多能干细胞
从原始生殖细胞分化出多能干细胞
DOI：
--
发表时间：
2011
期刊：
影响因子：
--
作者：
[中村太郎, 他, 宮川信一, Ogino H. and Ochi H., 永松剛・小坂威雄・田久保圭誉・大家基嗣・須田年生]
通讯作者：
永松剛・小坂威雄・田久保圭誉・大家基嗣・須田年生
Ataxia-telangiectasia mutated (ATM) deficiency decreases reprogramming efficiency and leads to genomic instabilityin iPS cells.
共济失调毛细血管扩张突变 (ATM) 缺陷会降低重编程效率并导致 iPS 细胞基因组不稳定。
共济失调毛细血管扩张突变 (ATM) 缺陷会降低重编程效率并导致 iPS 细胞基因组不稳定。
DOI：
--
发表时间：
2011
期刊：
Biochem Biophys Res Commun. 407(2)
影响因子：
--
作者：
[Kinoshita T, Nagamatsu G, Kosaka T, Takubo K, Hotta A, Ellis J, Suda T.]
通讯作者：
Suda T.
A germ cell specific gene, Prmt5 works as somatic cell reprogramming
Prmt5 是一种生殖细胞特异性基因，可作为体细胞重编程基因
Prmt5 是一种生殖细胞特异性基因，可作为体细胞重编程基因
DOI：
--
发表时间：
2011
期刊：
J Biol Chem
影响因子：
4.8
作者：
[Nagamatsu G, Kosaka T, Kawasumi M, Kinoshita T, Takubo K, Akiyama H, Sudo T, Kobayashi T, Oya M, and Suda T]
通讯作者：
and Suda T
Quality control of iPS cells by studying differentiation resistance.
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批准号：23618011
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项目类别：Grant-in-Aid for Scientific Research (C)
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资助金额：$3.41万
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财政年份：2011
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负责人：NAGAMATSU Go
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依托单位：
海外基金
