Characterization of the skin fibroblast, and induction of the artificial wound epidermis aiming for limb regeneration in mice

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To clarify if mammalians can be induced to regenerate their limbs like amphibians do, two things were examined in neonatal mice as below. 1) Do skin fibroblasts maintain pattern formation potency? 2) Can the amphibian-type wound epidermis be formed on the amputation stump? In the organ culture system, even in mice, the amputation surface was covered by thin epidermal sheet within a few days, and the morphology of the sheet was similar to the amphibian-type wound epidermis. Those results suggest that the early events of amphibian limb regeneration might be inducible in neonatal mice