Pathogenesis of rabies virus in neuronal cells

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Rabies is a lethal zoonotic disease and its causative agent is rabies virus, which infects in neurons. In the present study, experimental studies using laboratory animals and cultured cells were performed to clarify following two questions ; which viral factors induce dysfunction of neurons? And which immune response is important for the virus clearance from central nervous system (CNS)? By experimental intracerebral vaccination, it was clearly shown that virus-specific antibodies were highly induced in CNS and may contribute to the virus neutralization. Further, virus nucleoprotein interacted with some transcripts of neuronal cells suggesting the interference of host gene expression which may have roles in the pathogenesis of rabies.