Development of Bioactive Heterocycles by Tin-Free C1 Introduction Radical Process

由于自由基反应的不可缺少的实用性和锡试剂的毒性，锡自由基工艺的发展是一个重要的研究领域。我们已经开发了二甲基锌和三乙基硼烷介导的锡自由基过程。在这个研究项目中，我们发现了三氯化铁的加速作用，烷基马来酸的一种有趣的反应转换，N-烷氧基甲酰亚胺的高效接受自由基的能力，以及亚胺的异氰酸酯生成反应。

Development of tin-free radical process is an important research field because of the indispensable utility of radical reactions and the toxicity of tin reagents. We have already developed dimethylzinc-and triethylborane-mediated tin-free radical processes. During this research project to increase the scope of our process, we found the acceleration effect of ferric chloride, an interesting reaction switching of alkylidenemalonate, efficient radical accepting ability of N-alkoxycarbonyl-imine, and isocyanate forming reaction of the imine.