Development of artificial pancreas based on an LBL microcapsule

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Sugar-sensitive microcapsules containing insulin (artificial pancreas) were prepared by a layer-by-layer (LBL) deposition of alginic acid and phenylboronic acid-modified poly(allylamine) on the surface of a calcium carbonate (CaCO_3) microparticle in which insulin had been embedded, followed by dissolution of the CaCO_3 core. The sugar-triggered release of insulin was explained on the basis of decomposition of the microcapsules, which in turn was caused by competitive binding of added sugar to the phenylboronic acid moieties in the LbL film.