Investigation into mechanism of inhibitive cholesterol absorption by plant sterols and the novel method

在模型肠液中研究了几种植物甾醇/甾醇的降胆固醇作用机制。一类甾醇/甾烷醇物质分子结构的轻微差异会影响胆固醇在模型肠液中的溶解度。竞争增溶的结果表明，胆甾烷醇具有最大的降胆固醇作用，降低胆固醇溶解度的35%，在一个单一的增溶系统。降低胆固醇的作用顺序为<油菜甾醇<豆甾醇<岩藻甾醇<菜油甾醇<谷甾醇<胆甾醇。

The mechanism of cholesterol lowering by the addition of several kinds of plant sterols/sterols was investigated in model intestinal solution. Slight differences in the molecular structures of a category of sterol/stanol species affect the solubility of cholesterol in a model intestinal solution. The results of competitive solubilization revealed that cholestanol has the largest cholesterol-lowering effect, decreasing cholesterol solubility to 35% of that in a single solubilizate system. The cholesterol-lowering effect increase in the order of<brassicasterol<stigmasterol<fucosterol<campesterol<sitostanol<sitosterol<cholestanol.